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首页> 外文会议>Biophotonics and Immune Responses; Progress in Biomedical Optics and Imaging; vol.7 no.10 >Light and Immune Systems: Activation of Immunological Activities
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Light and Immune Systems: Activation of Immunological Activities

机译：灯光和免疫系统：免疫活动的激活

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摘要

Light has been used to treat diseases for hundreds of years. Convenient and powerful light sources such as lasers make photomedicine a major branch in diseases treatment and detection. Originally, light was often used for local treatment, using photomechanical, photochemical, photothermal reactions and photomodulation as the major mechanisms. More and more investigators have become interested in the systemic effects of light, particularly in its effects on immune systems. Much work has been done to activate and/or enhance the host immune system to combat cancer, either using light as a direct tool or as an adjuvant method. Light has long been used for assisting disease detection and diagnosis. Advances in light technology have made photo-diagnostics ever more precise spatially and temporally. Many techniques facilitate observation of bio-molecule interactions and other biological processes at the cellular level, hence providing opportunities to detect and monitor immune activities. This manuscript will review recent photo-immunological research in treatment of cancer. The recent development of combination therapies involving lasers will be presented. Specifically, the results of cancer treatment using laser photothermal interaction, either with or without additional immunological stimulation will be discussed. The immunological effects of photodynamic therapy (PDT), and of its combination with immunotherapy in cancer treatment will also be discussed. Much interest has been recently concentrated in the immunological responses after laser treatment. Such responses at cellular and molecular levels will be discussed. The effect of these treatment modalities on the distant metastases also showed promise of light induced antitumor immunity. The combination therapy and induced immunological responses appear to be the key for long-term control of tumors.
机译：光已被用于治疗疾病数百年。便捷而强大的光源（例如激光）使光医学成为疾病治疗和检测的主要分支。最初，光通常用于光化学，光化学，光热反应和光调制等主要机理的局部治疗。越来越多的研究人员对光的全身作用，特别是对免疫系统的作用感兴趣。使用光作为直接工具或作为佐剂方法，已经进行了许多工作来激活和/或增强宿主免疫系统以对抗癌症。长期以来，光一直用于辅助疾病的检测和诊断。光技术的进步使光诊断在空间和时间上变得更加精确。许多技术有助于在细胞水平上观察生物分子相互作用和其他生物过程，因此提供了检测和监测免疫活性的机会。该手稿将回顾最近在癌症治疗中的光免疫学研究。将介绍涉及激光的联合疗法的最新发展。具体而言，将讨论在有或没有其他免疫刺激的情况下使用激光光热相互作用进行癌症治疗的结果。还将讨论光动力疗法（PDT）的免疫学作用及其在癌症治疗中与免疫疗法的结合。最近，人们非常关注激光治疗后的免疫反应。将讨论细胞和分子水平的此类反应。这些治疗方式对远处转移的影响也显示出光诱导的抗肿瘤免疫的希望。联合治疗和诱导的免疫反应似乎是长期控制肿瘤的关键。

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