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Detection of squamous carcinoma cells using gold nanoparticles

机译：使用金纳米颗粒检测鳞状癌细胞

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摘要

The goal of this study is to use gold nanoparticle as a diagnostic agent to detect human squamous carcinoma cells. Gold nanoparticles were synthesized and the gold nanoparticle size was 34.3 ± 6.2 run. Based on the over-expression of epidermal growth factor receptor (EGFR) biomarkers in squamous carcinoma cells, we hypothesized that EGFR could be a feasible biomarker with a target moiety for detection. We further modified polyclonal antibodies of EGFR on the surface of gold nanoparticles. We found selected squamous carcinoma cells can be selectively detected using EGFR antibody-modified gold nanoparticles via receptor-mediated endocytosis. Cell death was also examined to determine the survival status of squamous carcinoma cells with respect to gold nanoparticle treatment and EGFR polyclonal antibody modification.
机译：这项研究的目的是使用金纳米颗粒作为诊断剂来检测人鳞状癌细胞。合成了金纳米颗粒，金纳米颗粒尺寸为34.3±6.2nm。基于鳞状癌细胞中表皮生长因子受体（EGFR）生物标志物的过表达，我们假设EGFR可能是一种具有检测目标部分的可行生物标志物。我们进一步修饰了金纳米颗粒表面上EGFR的多克隆抗体。我们发现可以通过受体介导的内吞作用，使用EGFR抗体修饰的金纳米颗粒选择性检测鳞状癌细胞。还检查了细胞死亡以确定相对于金纳米颗粒治疗和EGFR多克隆抗体修饰的鳞状细胞的存活状态。

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  • 来源
    《Biophotonics and immune responses X》|2015年|93240N.1-93240N.5|共5页
  • 会议地点 San Francisco CA(US)
  • 作者

    Wei-Yun Dai; Sze-tsen Lee; Yih-Chih Hsu;

  • 作者单位

    Department of Chemistry, Chung Yuan Christian University, Taoyuan, Taiwan, 32023, ROC;

    Dept of chemistry, Chung Yuan Christian University, 200, Chung-Pei Rd, Chung-Li,Taoyuan320, Taiwan, ROC,Center for Nanotechnology, Chung Yuan Christian University, Taoyuan, Taiwan, 32023, ROC;

    Center for Nanotechnology, Chung Yuan Christian University, Taoyuan, Taiwan, 32023, ROC,Dept of Bioscience Technology, Chung Yuan Christian University, 200, Chung-Pei Rd, Chung-Li, Taoyuan 320, Taiwan, ROC,Institute of Biomedical Technology, Chung Yuan Christian University, Taoyuan, Taiwan, 32023, ROC;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Gold nanoparticles; epidermal growth factor receptor; squamous carcinoma cells;

    机译：金纳米粒子；表皮生长因子受体；鳞状癌细胞;

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