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Treating cutaneous squamous cell carcinoma using ALA PLGA nanoparticle-mediated photodynamic therapy in a mouse model

机译：使用ALA PLGA纳米粒子介导的光动力疗法在小鼠模型中治疗皮肤鳞状细胞癌

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摘要

Background: Squamous cell carcinoma (SCC) is a common skin cancer and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted ALA delivery for topical photodynamic therapy (PDT) of cutaneous SCC. Methods: UV-induced cutaneous SCCs were established in hairless mice. ALA loaded polylactic-co-glycolic acid (PLGA) NPs were prepared and characterized. The kinetics of ALA PLGA NPs-induced protoporphyrin Ⅸ (PpⅨ) fluorescence in SCCs, therapeutic efficacy of ALA NP-mediated PDT, and immune responses were examined. Results: PLGA NPs could enhance PpⅨ production in SCC. ALA PLGA NP mediated topical PDT was more effective than free ALA of the same concentration in treating cutaneous SCC. Conclusion: PLGA NPs provide a promising strategy for delivering ALA in topical PDT of cutaneous SCC.
机译：背景：鳞状细胞癌（SCC）是一种常见的皮肤癌，其治疗仍然很困难。这项研究的目的是评估纳米（NP）辅助的ALA递送对皮肤SCC局部光动力疗法（PDT）的有效性。方法：在无毛小鼠中建立紫外线诱导的皮肤SCC。制备并表征了负载ALA的聚乳酸-乙醇酸（PLGA）NP。检查了ALA PLGA NPs诱导的鳞癌中原卟啉Ⅸ（PpⅨ）荧光的动力学，ALA NP介导的PDT的治疗效果以及免疫应答。结果：PLGA NPs可以增强SCC中PpⅨ的产生。 ALA PLGA NP介导的局部PDT在治疗皮肤SCC中比相同浓度的游离ALA更有效。结论：PLGA NPs为在皮肤SCC局部PDT中递送ALA提供了一种有前途的策略。

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  • 来源
    《Biophotonics and immune responses X》|2015年|93240U.1-93240U.12|共12页
  • 会议地点 San Francisco CA(US)
  • 作者

    Xiaojie Wang; Lei Shi; Qingfeng Tu; Hongwei Wang; Haiyan Zhang; Peiru Wang; Linglin Zhang; Zheng Huang; Xiuli Wang; Feng Zhao; Hansen Luan;

  • 作者单位

    Shanghai Skin Diseases Clinical College of Anhui Medical University, People's Republic of China,Shanghai Skin Disease Hospital, Shanghai, People's Republic of China;

    Shanghai Skin Disease Hospital, Shanghai, People's Republic of China;

    Shanghai Skin Disease Hospital, Shanghai, People's Republic of China;

    Huadong Hospital, Fudan University, Shanghai, People's Republic of China;

    Shanghai Skin Disease Hospital, Shanghai, People's Republic of China;

    Shanghai Skin Disease Hospital, Shanghai, People's Republic of China;

    Shanghai Skin Disease Hospital, Shanghai, People's Republic of China;

    MOE Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Normal University, Fuzhou, People's Republic of China;

    Shanghai Skin Disease Hospital, 1278 Baode Road, Shanghai 200443, People's Republic of China;

    National Pharmaceutical Engineering Research Center, China State Institute of Pharmaceutical Industry, Shanghai, People's Republic of China;

    National Pharmaceutical Engineering Research Center, China State Institute of Pharmaceutical Industry, Shanghai, People's Republic of China;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    5-Aminolevulinicacid (ALA); polylactic-co-glycolic acid (PLGA); nanoparticles (NPs); cutaneous squamous cell carcinoma (SCC); photodynamic therapy (PDT); microneedling;

    机译：5-氨基乙酰丙酸（ALA）;聚乳酸-乙醇酸（PLGA）；纳米颗粒（NPs）;皮肤鳞状细胞癌（SCC）;光动力疗法（PDT）；微针;

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