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首页> 外文期刊>International Journal of Nanomedicine >Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model
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Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model

机译：用5-氨基乙酰丙烯酸聚乳酸 - 共乙醇纳米粒子介导的小鼠模型中介导的光动力治疗治疗皮肤鳞状细胞癌

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Background: Squamous cell carcinoma (SCC) is a common skin cancer, and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted 5-aminolevulinic acid (ALA) delivery for topical photodynamic therapy (PDT) of cutaneous SCC.Materials and methods: Ultraviolet-induced cutaneous SCCs were established in hairless mice. ALA-loaded polylactic-co-glycolic acid (PLGA) NPs were prepared and characterized. The kinetics of ALA PLGA NP-induced protoporphyrin IX fluorescence in SCCs, therapeutic efficacy of ALA NP-mediated PDT, and immune responses were examined.Results: PLGA NPs enhanced protoporphyrin IX production in SCC. ALA PLGA NP-mediated topical PDT was more effective than free ALA of the same concentration in treating cutaneous SCC.Conclusion: PLGA NPs provide a promising strategy for delivering ALA in topical PDT of cutaneous SCC.
机译：背景：鳞状细胞癌（SCC）是一种常见的皮肤癌，其治疗仍然很困难。本研究的目的是评估纳米粒子（NP）的5-氨基乙酰丙酸（ALA）递送用于皮肤SCC的局部光动力疗法（PDT）的有效性。材料和方法：在无毛小鼠中建立紫外线诱发的皮肤SCC 。制备和表征了加载的聚乳酸共乙醇酸（PLGA）NPS。研究了SCCS中ALA PLGA NP诱导的原子卟啉IX荧光的动力学，ALA NP介导的PDT的治疗效果，以及免疫应答。结果：PLGA NPS在SCC中增强原子卟啉IX生产。 ALA PLGA NP介导的局部PDT比处理皮肤SCC的相同浓度的游离ALA更有效。结论：PLGA NPS提供了一种有望的策略，用于在皮肤SCC的局部PDT中递送ALA。

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