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首页> 外文会议>Conference on Optical Coherence tomography and coherence domain optical methods in biomedicine >Ultra-high speed OCT allows measurement of intraocular pressure, corneal geometry, and corneal stiffness using a single instrument
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Ultra-high speed OCT allows measurement of intraocular pressure, corneal geometry, and corneal stiffness using a single instrument

机译：超高速OCT允许使用单个仪器测量眼内压，角膜几何形状和角膜硬度

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摘要

Screening for ocular diseases, such as glaucoma and keratoconus, includes measuring the eye-globe intraocular pressure (IOP) and corneal biomechanical properties. However, currently available clinical tools cannot quantify corneal tissue material parameters, which can provide critical information for detecting diseases and evaluating therapeutic outcomes. Here, we demonstrate measurement of eye-globe IOP, corneal elasticity, and corneal geometry of in situ porcine corneas with a technique termed applanation optical coherence elastography (Appl-OCE) with single instrument. We utilize an ultrafast phase-sensitive optical coherence tomography system comprised of a 4X buffered Fourier domain mode-locked swept source laser with an A-scan rate of～1.5 MHz and a 7.3 kHz resonant scanner. The IOP was measured by imaging the response of in situ porcine corneas to a large force air-puff. As with other noncontact tonometers, the time when the cornea was applanated during the inwards and outwards motion was correlated to a measure air-pressure temporal profile. The IOP was also measured with a commercially available rebound tonometer for comparison. The stiffness of the corneas was assessed by directly imaging and analyzing the propagation of a focused micro air-pulse induced elastic wave, and the corneal geometry was obtained from the OCT structural image. Our results show that corneal thickness decreased as IOP increased, and that corneal stiffness increased with IOP. Moreover, the IOP measurements made by Appl-OCE were more closely correlated with the artificially set IOP than the rebound tonometer, demonstrating the capabilities of Appl-OCE to measure corneal stiffness, eye-globe IOP, and corneal geometry with a single instrument.
机译：筛查诸如青光眼和圆锥角膜之类的眼病包括测量眼球眼内压（IOP）和角膜生物力学特性。但是，当前可用的临床工具无法量化角膜组织材料参数，这可以为检测疾病和评估治疗效果提供关键信息。在这里，我们演示了使用称为扁平化光学相干弹性成像（Appl-OCE）的单仪器技术测量原位猪角膜的眼球IOP，角膜弹性和角膜几何形状。我们利用超快相敏光学相干断层扫描系统，该系统由4X缓冲傅里叶域锁模扫频源激光器组成，其A扫描速率约为1.5 MHz，并具有7.3 kHz共振扫描仪。通过成像原位猪角膜对大力气雾的反应来测量IOP。与其他非接触式眼压计一样，在向内和向外运动期间角膜扁平的时间与测量的气压时间曲线相关。还使用可商购的回弹眼压计测量IOP以进行比较。通过直接成像和分析聚焦微空气脉冲诱发的弹性波的传播来评估角膜的刚度，并从OCT结构图像获得角膜的几何形状。我们的结果表明，角膜厚度随着IOP的增加而降低，并且角膜硬度随IOP的增加而增加。此外，与回弹眼压计相比，Appl-OCE进行的IOP测量值与人工设置的IOP的关系更为紧密，这表明Appl-OCE能够通过单个仪器测量角膜硬度，眼球IOP和角膜几何形状。

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