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首页> 外文会议>China-Japan Symposium on Pharmaceutical Preparations and Particulate Design; 20060515-17; Shenyang(CN) >Studies on the Stability of the Choramphenicol in the Microemulsion Based Ocular Drug Delivery Systems
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Studies on the Stability of the Choramphenicol in the Microemulsion Based Ocular Drug Delivery Systems

机译：基于微乳剂的眼用药物输送系统中氯霉素的稳定性研究

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摘要

Eye drops are the most used dosage form by ocular route and choramphenicol is the main effective drug in the common used eye drops. However, the drug delivery system of eye drops have several disadvantages, such as a very low bioavailability (1～10%) of the drugs which must be absorbed at this site and must be inserted several times a day. Also, the effective component, that is choramphenicol, has very low solubility in water and easily hydrolyzes. The microemulsions are optically isotropic and thermodynamically stable systems. There are three different basic structural types of microemulsions: oil-in-water (o/w), water-in-oil (w/o) and finally, bicontinuous structures (B.C.). In all these cases, the surfactant forms a film at the internal interface that separates the water and oil domains. The presence of the co-surfactant is often required in order to lower the interfacial tension of this interface because a low interfacial tension is essential for the formation of microemulsions.
机译：滴眼剂是眼用途径中最常用的剂型，而氯霉素是常用滴眼剂中的主要有效药物。但是，滴眼剂的药物输送系统有几个缺点，例如必须在该部位吸收并且每天必须插入几次的药物的生物利用度很低（1〜10％）。而且，有效成分即氯苯甲酚在水中的溶解度非常低，并且容易水解。微乳液是光学各向同性和热力学稳定的体系。微乳液具有三种不同的基本结构类型：水包油（o / w），油包水（w / o）和最后是双连续结构（B.C.）。在所有这些情况下，表面活性剂都会在内部界面形成一层膜，将水域和油域分开。通常需要存在辅助表面活性剂以降低该界面的界面张力，因为低界面张力对于微乳液的形成是必不可少的。

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