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Interaction of sunscreen TiO_2 nanoparticles with skin and UV light: penetration, protection, phototoxicity

机译：防晒TiO_2纳米粒子与皮肤和紫外线的相互作用：渗透，保护，光毒性

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摘要

Titanium dioxide (TiO_2) nanoparticles are extensively used nowadays in sunscreens as protective compounds for human skin from UV radiation. In this paper, such particles are investigated from the viewpoint of penetration into living skin, UV protective properties (compared with silicon (Si) particles) and as sources of free radicals if UV-irradiated. We show that: a) even after multiple applications, the particles are located within the uppermost 3-(im-thick part of the skin; b) the optimal sizes are found to be 62 nm and 55 nm, respectively for TiO_2 and Si particles for 310-nm light and, correspondingly, 122 and 70 nm - for 400-nm radiation; c) if applied onto glass, small particles of 25 nm in diameter produce an increased amount of free radicals compared to the larger ones of 400 nm in diameter and placebo itself; however, if applied onto porcine skin in vitro, there is no statistically distinct difference in the amount of radicals generated by the two kinds of particles on skin and by the skin itself. This proves that although particles as part of sunscreens produce free radicals, the effect is negligible in comparison to the production of radicals by skin in vitro.
机译：如今，二氧化钛（TiO_2）纳米粒子已广泛用于防晒霜中，作为人体皮肤免受紫外线辐射的保护性化合物。在本文中，从渗透到活体皮肤，紫外线防护性能（与硅（Si）颗粒相比）以及作为紫外线辐射源的自由基的角度研究了此类颗粒。我们显示：a）即使经过多次应用，这些颗粒仍位于皮肤的最上层3-（im-in-thick部分）内； b）对于TiO_2和Si颗粒，最佳尺寸分别为62 nm和55 nm对于310 nm的光，相应地为122和70 nm-对于400 nm的辐射； c）如果将其涂在玻璃上，则直径为25 nm的小颗粒与直径较大的400 nm的安慰剂本身相比，会产生更多的自由基；但是，如果在体外应用到猪皮肤上，由皮肤上的两种颗粒和皮肤本身产生的自由基数量在统计学上没有明显的不同。这证明，尽管作为防晒剂一部分的颗粒产生自由基，但与体外皮肤产生自由基相比，该作用可以忽略不计。

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  • 来源
    《Clinical and biomedical spectroscopy》|2009年|P.736822.1-736822.6|共6页
  • 会议地点 Munich(DE)
  • 作者

    Alexey Popov; Jilrgen Lademann; Alexander Priezzhev; Risto Myllylae;

  • 作者单位

    Optoelectronics and Measurement Techniques Laboratory, Faculty of Technology, University of Oulu, P.O. Box 4500, FI-90014, Oulu, Finland International Laser Center, Lomonosov Moscow State University, Moscow, 119991, Russia;

    Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Medical Faculty Charite, Humboldt University Berlin, Berlin, Germany;

    International Laser Center, Lomonosov Moscow State University, Moscow, 119991, Russia;

    Optoelectronics and Measurement Techniques Laboratory, Faculty of Technology, University of Oulu, P.O. Box 4500, FI-90014, Oulu, Finland;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医用物理学;
  • 关键词

    nanoparticles; UV light; skin; sunscreen; phototoxicity;

    机译：纳米粒子紫外线;皮肤;防晒霜光毒性;

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