首页> 外文会议>Colloidal nanoparticles for biomedical applications XII >COLLOIDAL SILICON QUANTUM DOTS: FROM PREPARATION TO THE MODIFICATION OF SELF-ASSEMBLED MONOLAYERS FOR BIOIMAGING AND SENSING APPLICATIONS
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COLLOIDAL SILICON QUANTUM DOTS: FROM PREPARATION TO THE MODIFICATION OF SELF-ASSEMBLED MONOLAYERS FOR BIOIMAGING AND SENSING APPLICATIONS

机译:胶体硅量子点:从制备到用于生物成像和传感应用的自组装单分子膜的改性

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摘要

In this paper we present recent advances in Foerster resonance energy transfer (FRET) sensing and bioimaging using nontoxic silicon quantum dots. (SiQDs) In our work, we prepare SiQDs-dye conjugates, with SiQDs serving as the donor which are covalently attached to organic dye acceptors via self-assembled monolayer linkers. Enzymatic cleavage of the peptide leads to changes in FRET response which was monitored using fluorescence lifetime imaging microscopy (FLIM-FRET). The combination of interfacial design and optical imaging presented in this work opens new opportunities for bio-applications using nontoxic silicon quantum dots.
机译:在本文中,我们介绍了使用无毒硅量子点进行的Foerster共振能量转移(FRET)传感和生物成像的最新进展。 (SiQDs)在我们的工作中,我们准备了SiQDs-染料共轭物,其中SiQDs作为供体,通过自组装单层连接子共价连接到有机染料受体上。肽的酶促切割导致FRET反应发生变化,可使用荧光寿命成像显微镜(FLIM-FRET)进行监测。这项工作中介绍的界面设计和光学成像相结合,为使用无毒硅量子点的生物应用提供了新的机会。

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  • 会议地点 San Francisco(US)
  • 作者单位

    School of Chemistry, Australian Centre for NanoMedicine, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales, Sydney, NSW 2052, Australia,EMBL Australia Node in Single Molecule Science, School of Medical Sciences, ARC Centre of Excellence in Advanced Molecular Imaging, The University of New South Wales, Sydney, NSW 2052, Australia;

    School of Chemistry, Australian Centre for NanoMedicine, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales, Sydney, NSW 2052, Australia;

    School of Chemistry, Australian Centre for NanoMedicine, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales, Sydney, NSW 2052, Australia;

    School of Chemistry, Australian Centre for NanoMedicine, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales, Sydney, NSW 2052, Australia;

    School of Chemistry, Australian Centre for NanoMedicine, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales, Sydney, NSW 2052, Australia;

    School of Chemistry, Australian Centre for NanoMedicine, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales, Sydney, NSW 2052, Australia;

    School of Chemistry, Australian Centre for NanoMedicine, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales, Sydney, NSW 2052, Australia;

    School of Chemistry, Australian Centre for NanoMedicine, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales, Sydney, NSW 2052, Australia;

    EMBL Australia Node in Single Molecule Science, School of Medical Sciences, ARC Centre of Excellence in Advanced Molecular Imaging, The University of New South Wales, Sydney, NSW 2052, Australia;

    School of Chemistry, Australian Centre for NanoMedicine, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales, Sydney, NSW 2052, Australia;

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  • 正文语种 eng
  • 中图分类
  • 关键词

    Quantum dots; silicon; FRET; FLIM; sensor;

    机译:量子点;硅;烦恼; FLIM;传感器;

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