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Synthesis and manipulation of multifunctional, fluorescent-magnetic nanoparticles for single molecule tracking

机译：用于单分子跟踪的多功能荧光磁性纳米粒子的合成和操作

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Heterogeneous nanostructures that possess multiple properties as a result of their differing constituent materials have attracted significant interest in the last few years. In particular, fluorescent-magnetic nanostructures have potential applications in imaging, separations, and single molecule tracking as a result of their fluorescent and magnetic properties. Here we report the synthesis of fluorescent-magnetic nanocomposites composed of fluorescent semiconductor quantum dots or graphitic carbon nanoparticles and magnetic iron oxide nanoparticles. We have developed synthetic strategies using either micellular or polymer encapsulation, yielding composites from -10 - 100s of nms. Composites maintain the fluorescent and magnetic properties of their constituent materials. These composites can be used for in vitro and in vivo imaging using fluorescent or magnetic (e.g., MRI) modalities. Additionally, we describe the manipulation of these composites using magnetic instrumentation. In particular, we have designed a magnetic needle that can be used to manipulate nanocomposites. Particles as small as 30 nm can be manipulated while simultaneous observed through their fluorescent property. Single particle status can be confirmed through quantum dot blinking, demonstrating the potential of these composites for single molecule tracking.
机译：由于其不同的构成材料而具有多种特性的异质纳米结构在最近几年引起了极大的兴趣。尤其是，荧光磁性纳米结构由于其荧光和磁性性质而在成像，分离和单分子跟踪中具有潜在的应用。在这里，我们报告由荧光半导体量子点或石墨碳纳米粒子和磁性氧化铁纳米粒子组成的荧光磁性纳米复合材料的合成。我们已经开发出使用微孔或聚合物封装的合成策略，可产生-10-100纳米的复合材料。复合材料保持其组成材料的荧光和磁性。这些复合材料可用于利用荧光或磁性（例如MRI）形式的体外和体内成像。此外，我们描述了使用磁性仪器对这些复合材料的处理。特别是，我们设计了一种可用于处理纳米复合材料的磁针。可以操纵小至30 nm的颗粒，同时通过其荧光特性对其进行观察。可以通过量子点闪烁来确认单粒子状态，这表明了这些复合材料在单分子追踪中的潜力。

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