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首页> 外文会议>Computational Intelligence in Bioinformatics and Computational Biology, 2009. CIBCB '09 >Comparison of feature selection techniques for viral DNA replication origin prediction
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Comparison of feature selection techniques for viral DNA replication origin prediction

机译：病毒DNA复制起点预测的特征选择技术比较

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摘要

As the replication of their DNA genomes is a central step in the reproduction of many viruses, procedures to find replication origins, which are initiation sites of the DNA replication process, are of great importance for controlling the growth and spread of such viruses. Existing computational methods for viral replication origin prediction have mostly been designed to use only the composition of a region of viral DNA to predict if such region is an ORI or not. This paper proposes the application of several feature selection techniques to help find the most significant features of the replication origins in herpesviruses. The results suggest that features based on the relative positions of the regions in the genomes containing replication origins and the information about the subfamily of the virus can be highly useful features to be incorporated into the computational tools for viral replication origin prediction.
机译：由于其DNA基因组的复制是许多病毒复制的中心步骤，因此寻找复制起点（即DNA复制过程的起始位点）的过程对于控制此类病毒的生长和传播非常重要。现有的用于病毒复制起点预测的计算方法主要被设计为仅使用病毒DNA区域的组成来预测该区域是否为ORI。本文提出了几种特征选择技术的应用，以帮助找到疱疹病毒中复制起点的最重要特征。结果表明，基于包含复制起点的基因组中区域的相对位置的特征以及有关病毒亚科的信息可能是非常有用的特征，可以纳入到病毒复制起点预测的计算工具中。

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