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首页> 外文会议>Computational Life Sciences II; Lecture Notes in Bioinformatics; 4216 >A Hybrid Grid and Its Application to Orthologous Groups Clustering
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A Hybrid Grid and Its Application to Orthologous Groups Clustering

机译：混合网格及其在正交群体聚类中的应用

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Orthologous groups are useful in the genome annotation, studies on gene evolution, and comparative genomics. However, the construction of orthologous groups is difficult to automate and takes so much time as the number of genome sequences increases. Furthermore, it is not easy to guarantee the accuracy of the automatically constructed orthologous groups. We propose an automatic orthologous group construction system for a large number of genomes. A hybrid grid computer system, consisting of 40 PCs, has been devised for fast construction of the orthologous groups from large number of genome sequences. The grid system constructs orthologous groups for 89 complete prokaryotes genomes just in a week (it takes 8 months on a single computer system). Furthermore, the system provides good extensibility for adopting new genomes in the existing orthologous groups. In the real experiment of the orthologous group constructions, more than 85% of the constructed orthologous groups coincide with those of KO (KEGG Ortholog) and COGs (Clusters of Orthologous Group of Proteins). Note that KO and COGs have been constructed manually or semi-automatically at the sacrifice of the extensibility for newly completed genomes.
机译：直系同源群可用于基因组注释，基因进化研究和比较基因组学。但是，直向同源基团的构建难以自动化，并且随着基因组序列数量的增加而花费大量时间。此外，要保证自动构建的直系同源群的准确性并不容易。我们提出了用于大量基因组的自动直系同源构建系统。已经设计了一种由40台PC组成的混合网格计算机系统，用于从大量的基因组序列中快速构建直系同源基团。网格系统仅在一周内即可为89个完整的原核生物基因组构建直系同源群（在单个计算机系统上需要8个月）。此外，该系统为在现有直系同源群中采用新基因组提供了良好的可扩展性。在直系同源基团构建的真实实验中，超过85％的直系同源基团与KO（KEGG Ortholog）和COGs（直系同源蛋白质组）吻合。请注意，KO和COG已通过手动或半自动方式构建，但牺牲了新完成基因组的可扩展性。

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