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首页> 外文会议>Computational Neuroscience Meeting(CNS03); 20030705-09; Alicante(ES) >Analysis of dendritic distribution of voltage-dependent channels effects on EPSP and its reciprocal inhibition in α-motoneurons: computer model
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Analysis of dendritic distribution of voltage-dependent channels effects on EPSP and its reciprocal inhibition in α-motoneurons: computer model

机译：电压依赖性通道对EPSP的树突分布及其在α-运动神经元中的相互抑制作用的分析：计算机模型

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摘要

Modeling of excitation and inhibition of morphologically and physiologically characterized triceps surea motoneuron (MN 42) was executed by a NEURON simulator. The voltage-dependent channels of MN 42 were allocated on six dendrites (the rest six dendrites remained passive) according to three types of distribution functions: a step function (SF), an exponential decay (ED, highest density proximally to the soma) and exponential rise (ER, highest density distally to the soma). Maximal densities of the sodium conductance varied between 0.01 and 0.06 S/cm~2. The peak of the EPSP became larger as the maximal density of the voltage-dependent channels is increased. In the SF distribution, with the highest total conductance (G, Siemens), the EPSP amplitudes were greater than these in the ER and ED models. The reciprocal EPSP inhibition in the model with the SF was most efficient in comparison to the ED and ER models. EPSP peak inhibition at ED and ER are similar, despite that the total active conductance in ED is about 10 times smaller than in ER distribution. The dependency of the inhibition on the density of the active conductance in the SF and ED models is not linear. We conclude that in an "ideal neuron" the presence of proximal voltage-dependent channels may boost distally located synaptic inputs thus "normalizing" the synaptic responses.
机译：由NEURON模拟器对形态和生理学特征的运动神经元三头肌（MN 42）的激发和抑制进行建模。 MN 42的电压相关通道根据三种分布函数分配在六个树突上（其余六个树突保持被动状态）：阶跃函数（SF），指数衰减（ED，靠近体细胞的最高密度）和指数上升（ER，远端的最高密度）。钠电导的最大密度在0.01和0.06 S / cm〜2之间变化。随着电压相关通道的最大密度增加，EPSP的峰值变得更大。在SF分布中，具有最高的总电导率（G，西门子），EPSP幅度大于ER和ED模型中的幅度。与ED和ER模型相比，具有SF的模型中对EPSP的抑制作用最有效。 ED和ER处的EPSP峰抑制相似，尽管ED中的总活性电导比ER分布小约10倍。 SF和ED模型中抑制对活性电导密度的依赖性不是线性的。我们得出结论，在“理想的神经元”中，近端电压依赖性通道的存在可能会增强位于远端的突触输入，从而使突触反应“正常化”。

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