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首页> 外文会议>Conference on Active and passive smart structures and integrated systems; 20090309-12; San Diego, CA(US) >Design and Operation of a Fully Implantable SMA Actuated Implant for Correcting Short Bowel Syndrome
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Design and Operation of a Fully Implantable SMA Actuated Implant for Correcting Short Bowel Syndrome

机译：矫正短肠综合征的完全可植入SMA驱动植入物的设计和操作

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摘要

Short Bowel Syndrome (SBS) is medical condition characterized by insufficient small intestine length, leading to improper nutrient absorption and significant mortality rates. The complications of current treatment methods have encouraged the development of a novel treatment method based on mechanotransduction, the process through which mechanical tensile loading induces longitudinal growth of intestine. Animal based studies with simple extension devices have demonstrated the potential of the treatment to grow healthy bowel, but an implantable device suitable for clinical use remains undeveloped. This paper presents the development of an instrumented fully implantable bowel extender based upon a shape memory alloy driven linear ratchet that can be controlled and monitored remotely. The overall bowel extender system is described with respect to specifications for pig experimental tests. The functionality of the mechanical and electrical subsystems of the device are detailed and experimentally validated on the bench top, in segments of living bowel tissue removed from a pig, and in cadaveric pigs. Mechanical loading characteristics and safe load limits on bowel tissue are identified. Results from these experiments establish the readiness of the device to be tested in living pigs, enabling studies to move one step closer to clinical studies.
机译：短肠综合症（SBS）是一种以小肠长度不足为特征的医疗疾病，导致营养吸收不良，死亡率高。当前治疗方法的复杂性鼓励了基于机械转导的新型治疗方法的发展，该过程是机械拉伸负荷诱导肠道纵向生长的过程。使用简单的伸展装置进行的基于动物的研究表明，该疗法具有促进健康肠生长的潜力，但仍未开发出适合临床使用的可植入装置。本文介绍了一种基于形状记忆合金驱动的线性棘轮的可完全植入式肠扩张器的开发，该线性棘轮可远程控制和监视。关于猪实验测试的规格描述了整个肠补充剂系统。该设备的机械和电气子系统的功能已在台式，从猪身上取出的活肠组织段以及尸体猪中进行了详细的实验验证。确定了肠组织的机械负荷特性和安全负荷极限。这些实验的结果确定了待测试设备在生猪中的准备状态，使研究更接近于临床研究。

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