首页> 外文会议>Conference on Femtosecond Laser Applications in Biology; 20040429; Strasbourg; FR >Femtosecond relativistic electron beam triggered early bioradical events
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Femtosecond relativistic electron beam triggered early bioradical events

机译:飞秒相对论电子束引发了早期生物自由基事件

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With the recent advent of table-top terawatt Ti:Sa laser amplifier systems, laser plasma interactions provide high-energy, femtosecond electron bunches, which might conjecture direct observation of radiation events in media of biological interest. We report on the first femtolysis studies using such laser produced relativistic electron pulses in the 2.5-15 MeV range. A real-time observation of elementary radical events is performed on water molecules and media containing an important disulfide biomolecule. The primary yield of a reducing radical produced in clusters of excitation-ionisation events (spurs) has been determined at t ~3.5 10~(-12) s. These data provide important information about the initial energy loss and spatial distribution of early radical events. Femtolysis studies devoted to a disulfide biomolecule is noteworthy as it is the first time that a primary ionisation event can be controlled by an ultrafast radical anion formation in the prethermal regime. This innovating domain foreshadows the development of new applications in radiobiology (microdosimetry at the nanometric scale). In the near future, electron femtolysis studies would clearly enhance the understanding of radiation-induced damages in biological confined spaces (aqueous groove of DNA and protein pockets).
机译:随着最近的台式兆瓦级Ti:Sa激光放大器系统的出现,激光等离子体相互作用提供了高能飞秒电子束,这可能推测可以直接观察到具有生物学意义的介质中的辐射事件。我们报告了使用这种激光在2.5-15 MeV范围内产生的相对论性电子脉冲进行的首次纤溶研究。在包含重要的二硫键生物分子的水分子和介质上进行基本自由基事件的实时观察。确定了在激发电离事件(杂散)簇中产生的还原自由基的主要产率为t〜3.5 10〜(-12)s。这些数据提供了有关早期自由基事件的初始能量损失和空间分布的重要信息。专注于二硫化物生物分子的Femtolysis研究是值得注意的,因为这是第一次可以在预热状态下通过超快自由基阴离子的形成来控制一次电离事件。这一创新领域预示着放射生物学(纳米级微剂量学)新应用的发展。在不久的将来,电子femtolysis研究将清楚地增强对辐射在生物密闭空间(DNA和蛋白质囊的水槽)中造成的损害的理解。

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