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首页> 外文会议>Conference on femtosecond laser applications in biology >Femtosecond relativistic electron beam triggered early bioradical events
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Femtosecond relativistic electron beam triggered early bioradical events

机译：飞秒相对论电子束触发了早期生物化事件

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With the recent advent of table-top terawatt Ti:Sa laser amplifier systems, laser plasma interactions provide high-energy, femtosecond electron bunches, which might conjecture direct observation of radiation events in media of biological interest. We report on the first femtolysis studies using such laser produced relativistic electron pulses in the 2.5-15 MeV range. A real-time observation of elementary radical events is performed on water molecules and media containing an important disulfide biomolecule. The primary yield of a reducing radical produced in clusters of excitation-ionisation events (spurs) has been determined at t ～3.5 10~(-12) s. These data provide important information about the initial energy loss and spatial distribution of early radical events. Femtolysis studies devoted to a disulfide biomolecule is noteworthy as it is the first time that a primary ionisation event can be controlled by an ultrafast radical anion formation in the prethermal regime. This innovating domain foreshadows the development of new applications in radiobiology (microdosimetry at the nanometric scale). In the near future, electron femtolysis studies would clearly enhance the understanding of radiation-induced damages in biological confined spaces (aqueous groove of DNA and protein pockets).
机译：随着最近桌面Terawatt Ti的出现：SA激光放大器系统，激光等离子相互作用提供高能，飞秒电子束，这可能会猜测生物学媒体媒体的辐射事件直接观察。我们在2.5-15MeV范围内使用这种激光产生的相对论电子脉冲产生的第一个飞脱石研究。对含有重要二硫化物生物分子的水分子和培养基进行基本自由基事件的实时观察。在T〜3.5 10〜（-12）S中确定了在激发 - 电离事件（马刺）簇中产生的还原基团的主要产率。这些数据提供了有关早期激进事件的初始能量损失和空间分布的重要信息。致专用于二硫化物生物分子的春季分解研究是值得注意的，因为它是首次通过前电离事件通过售价制度中超速自由基阴离子形成来控制。这一创新域预示着在辐射生物学中的新应用的开发（纳米尺度的微骨谱）。在不久的将来，电子飞析研究将明显增强对生物密闭空间（DNA水槽和蛋白质袋的水槽水槽中的辐射造成损伤的理解。

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