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首页> 外文会议>Conference on Laser and Noncoherent Light Ocular Effects: Epidemiology, Prevention, and Treatment III Jan 26-27, 2003 San Jose, California, USA >A new experimental analysis method clarifies spectral threshold of laser ocular bioeffects
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A new experimental analysis method clarifies spectral threshold of laser ocular bioeffects

机译：一种新的实验分析方法阐明了激光眼生物效应的光谱阈值

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摘要

For more than 10 years there have been discussions regarding the unexplainable significant variation of the ED_(50) attained with small changes in wavelength, found in the experimental results reported by the USAMRD-WRAIR. Previous studies showed that the probit analysis that was used to estimate the ED_(50) occasionally yield unreliable results in the special case of data gathered in dose-respond laser-tissue experiment. A reanalysis the data of the USAMRD-WRAIR revealed significant subject's dissimilarity that was not considered in the first analysis. However, though both the subjects dissimilarity and the potential of unreliable probit's estimates could contribute to the spectral ED_(50) variation, no satisfying analysis and expiation of spectral ED_(50) has yet been suggested. A new analysis method that inherently incorporates physical and statistical models will be presented. This method enables the identification of the laser damage mechanism and suggests a new spectral ED_(50). The method can, then, also disclose questionable data sections, which neither complies with the data majority nor follows physical causality.
机译：十多年来，人们一直在讨论关于ED_（50）的不可解释的显着变化，即随着波长的微小变化而获得的ED_（50）的显着变化，这是在USAMRD-WRAIR报告的实验结果中发现的。先前的研究表明，用于估计ED_（50）的概率分析偶尔会在剂量响应激光组织实验中收集到的特殊情况下产生不可靠的结果。重新分析USAMRD-WRAIR的数据后发现，受试者的显着性差异很大，而在首次分析中并未考虑。但是，尽管主题的相似性和不可靠的概率估计的可能性都可能导致频谱ED_（50）的变化，但尚未提出令人满意的频谱ED_（50）的分析和解释方法。将介绍一种固有地结合了物理和统计模型的新分析方法。该方法能够识别激光损伤机理并建议新的光谱ED_（50）。然后，该方法还可以披露可疑数据部分，这些部分既不符合数据多数，也不遵循物理因果关系。

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