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首页> 外文会议>Conference on Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical, Jan 20-23, 2002, San Jose, California >Modeling of laser-induced threshold damage in the peripheral retina
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Modeling of laser-induced threshold damage in the peripheral retina

机译：激光诱导的周围视网膜阈损伤的建模

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摘要

Though allowable (safe) energy doses of pulsed laser radiation have been determined in the central retina, the sensitivity of the peripheral retina to damage must also be assessed. We used results from ray-tracing in an eye model to estimate laser spot size at the retina and recent thermal model computations of damage thresholds to predict off-axis retinal injury from laser irradiation. The predictions were made for threshold exposures with a 532 nm, 10 ns, Nd:YAG laser beam that filled the dilated pupil (7 mm diameter). Results were compared to previously published measured energy doses at the cornea needed to produce a minimally visible lesion (MVL) in the peripheral retina of rhesus subjects. We predicted the threshold for injury at the macula, and at selected portions of peripheral retina out to 60° from the fovea. Both predictions and measured data were normalized to their respective macula values. Normalized predicted thresholds in the peripheral retina increased as a function of angular distance from the macula. This varied from the measured data which, on the other hand, were relatively insensitive to angular position in the peripheral retina. The difference is likely due to improvements in methods of assessing retinal injury that have been incorporated into the model.
机译：尽管已在中央视网膜中确定了脉冲激光辐射的允许（安全）能量剂量，但还必须评估周围视网膜对损伤的敏感性。我们使用眼睛模型中光线跟踪的结果来估计视网膜上的激光光斑大小，并使用损伤阈值的最新热模型计算来预测激光照射对轴外视网膜的伤害。对充满膨胀的瞳孔（直径7 mm）的532 nm，10 ns，Nd：YAG激光束的阈值曝光进行了预测。将结果与先前发表的在恒河猴的外周视网膜中产生最小可见病变（MVL）所需的角膜能量剂量进行比较。我们预测了黄斑和与视网膜中央凹相距60°的部分周围视网膜的损伤阈值。将预测和测量数据均归一化为其各自的黄斑值。周围视网膜的标准化预测阈值随着距黄斑角距离的增加而增加。另一方面，这与实测数据有所不同，实测数据对周围视网膜的角位置相对不敏感。差异可能是由于模型中合并的视网膜损伤评估方法的改进。

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