• 主题
高级搜索  >
历史搜索 清空历史
您现在的位置：首页> 中文期刊>医药卫生>五官科学>临床眼科杂志

临床眼科杂志

临床眼科杂志

CSTPCD

Journal of Clinical Ophthalmology
本刊是全国性眼科专业学术期刊，国内外公开发行。本刊1993年创刊，季刊，每期64页。1998年改为双月刊出版。2000年始扩版增页，改为大16开，每期88页出版，2002年每期96页出版。1993年至2002年共出版10卷48期，3000多篇论文。《临床眼科杂志》注重报道临床应用方面的研究论文，以及临床实践中的经验总结，新技术、新疗法的创立和应用。力求做到普及与提高相结合，帮助临床医师解决实际问题，提高诊疗水平。努力提高我国眼科学学术水平，为增进学科的建设和发展服务。本刊报导的范围：有关眼科学临床应用方面的研究论著，临床经验介绍、技术改进、调查研究、病例报告、综述与讲座、学术动态以及书刊消息等。
更多
  • 发文量：5171
  • 被引量：1208
  • H指数：1
  • 开始收录时间：1993(1)
  • CNKI综合因子：0.585
  • 维普期刊影响因子： 0.92
  • 万方期刊影响因子：1.12
  • 创刊时间：1993
  • 国内刊号/CN：34-1149/R
    国际刊号/ISSN：1006-8422
  • 发行周期：双月刊
    邮发代号：26-110
  • 主管单位：安徽医科大学；安徽眼科研究所
    主办单位：安徽医科大学；安徽眼科研究所
临床眼科杂志-联系信息
  • 主编：陈逖
  • 电话：0551-62923182 62923235
  • 邮箱：lcykzz@sina.com;hnfy@sohu.com
  • 地址：合肥市绩溪路218号
  • 邮编：230022
临床眼科杂志-获奖情况
  • 暂无获奖信息
  • 收录汇总
  • 刊内文献检索
  • 投稿信息

刊期浏览

相关中文期刊

相关中文会议

相关外文期刊

相关外文会议

最新期刊

热门期刊

临床眼科杂志 >2023年第5期

学科

年度

全选（0）
排序：
共4384条结果
  • 摘要：为促进眼科学专业领域的国际交流,使国内医师能够阅读到优秀的眼科学海外专著,中华国际医学交流基金会海外优秀医学专著引进项目编辑部于2012年8月组织出版了《眼科疾病的发病机制与治疗》一书。
  • 2.消息
  • 摘要：Objective To observe the efficacy of combined vitrectomy and lensectomy in the treatment of severe lens subluxation .Methods In this retrospective study , thirty-two eyes of 28 patients presented with severe lens subluxa-tion were treated with combined vitrectomy and lensectomy in our hospital from June 2010 to June 2013.Zonular fibers rup-ture were more than 180 degrees in all cases.Twenty-two eyes received foldable intraocular lens (IOL) implantation.All patients were followed up for 6 to 20 months (average 10.5 ±2.4 months).The observations included best corrected visual acuity (BCVA), endothelial cell density , intraocular pressure (IOP), IOL status, fundus and related complications .Re-sults BCVA improved (27 eyes, 84.38%) or maintained (4 eyes, 12.50%) after the surgery in majority of the pa-tients.Only in one eye (3.13%) BCVA became worse.There were no significant changes in endothelial cell density at 3 months and 6 months after the surgery .IOP were normal in all patients , and there was no anterior vitreous hernia observed . Conclusion Vitrectomy, lensectomy and foldable post chamber IOL placement for the treatment of severe lens subluxation could achieve optimal clinical outcomes with fewer complications .%目的：观察玻璃体切割联合晶状体切除术治疗严重晶状体不全脱位的临床疗效。方法回顾性分析我院2010年6月至2013年6月收治的严重晶状体不全脱位28例（32只眼），晶状体悬韧带断裂均超过180°。所有患者均经睫状体平坦部作闭合式玻璃体切割术，切除玻璃体及脱位的晶状体。其中22只眼联合折叠人工晶状体睫状沟缝线固定术。术后随访6～20个月，平均（10．5±2.4）个月。观察患者术后最佳矫正视力、内皮细胞计数、眼压、人工晶状体、眼底及并发症情况。结果术后与术前最佳矫正视力相比提高27只眼（84.38％），不变4只眼（12.50％），下降1只眼（3.13％）。术后6个月内皮细胞数与术前相比差异均无统计学意义（ P ＞0．05）。术后患者眼压均控制正常。术后所有患者前房未见玻璃体疝。结论玻璃体切割联合晶状体切除术治疗严重晶状体不全脱位术中、术后并发症少，联合行后房型折叠人工晶状体植入可取得较好临床效果。
  • 摘要：Objective To evaluate and analyze the long-term efficacy and safety of combined pterygium excision and conjunctival autografting for the treatment of primary pterygium .Methods Subjects included 113 patients (117 eyes) with primary pterygium who were treated in our hospital with combined pterygium excision and conjunctival limbal autograft transplantation .Among the subjects , sixty-five eyes received surgery alone , and the other 52 eyes received surgery and tropical medication therapies .Conjunctival autografts were obtained from upper temporal limbus and secured with 10-0 mon-ofilament nylon.All patients were followed for 33 to 54 months (mean 39 months).Results In 65 eyes that underwent surgery alone, pterygium recurred in four (6.15%) eyes.In 52 eyes that received surgery and tropical mitomycin C and steroids, only two eyes (3.85%) were found to had recurred pterygium .This difference was significant ( P <0.05). Conclusion We conclude that combined pterygium excision and conjunctival limbal autografting is effective and safe for the treatment of primary pterygium .Addition of tropical medications such as mitomycin C and steroids would further reduce the risk of recurrence .%目的：探讨翼状胬肉切除联合角膜缘干细胞移植及附加综合辅助治疗措施治疗翼状胬肉的临床远期疗效。方法回顾分析113例（117只眼）翼状胬肉切除联合角膜缘干细胞移植术病例，其中65只眼仅行常规手术，52只眼行常规手术联合综合辅助治疗。结果65只眼仅行常规手术有4只眼复发，复发率为6.15％；52只眼行常规手术联合综合辅助治疗措施后2只眼复发，复发率为3.85％。经统计学分析， P ＜0.05，差异有统计学意义。结论翼状胬肉切除联合角膜缘干细胞移植术治疗翼状胬肉安全、有效，尽量排除不利因素，采取综合辅助治疗措施可更有效地减少民办状胬肉术后复发率。
  • 摘要：我国著名眼科学家、中国共产党党员、国务院政府特殊津贴获得者、四川大学华西医院眼科教授罗成仁教授因病不幸于2014年7月3日4时19分逝世。享年91岁。罗成仁教授1923年出生于四川省成都市。早年就读于成都石室中学。1950年毕业于华西协合大学医学院，获美国纽约州立大学医学博士学位。先后担任四川大学华西医院眼科学教授、博士研究生导师和博士后研究合作导师：卫生部临床学科“眼底病研究”重点建设项目、四川省教育委员会和华西医科大学“国家211工程”重点学科点眼科的学科带头人：国家自然科学基金评议专家、国务院学位委员会博士点和硕士点通讯评议专家组成员。担任华西医科大学眼科副主任、主任共25年；历任成都市和四川省眼科学会主任委员。1992年获国务院特殊津贴。1953年作为成都市科学技术界青年代表出席在北京举行的“第二届全国青年代表大会”，受到毛泽东等党和国家领导人接见。1981、1994年分别获成都市先进科技工作者和劳动模范称号。1990年获国家教委颁发的“从事高校科技工作40年成绩卓著”的表彰证书和奖牌。1996年获“中美眼科学会”“金钥匙”奖。
  • 摘要：目的：观察配戴角膜塑形镜治疗青少年近视的临床疗效。方法连续选取我院2011年9月至2012年12月轻中度青少年近视患者共78例（156只眼）随机分为两组，框架眼镜组（A组）、角膜塑形镜组（B组），比较两组矫正后视力、屈光度、角膜曲率等情况。结果戴镜1年后，B组裸眼视力明显优于A组原框架眼镜矫正视力；B组患者的屈光度明显低于A组的屈光度（ P ＜0.05）；A组患者戴镜后角膜曲率较戴镜前增高，B组患者戴镜后角膜曲率较戴镜前下降，两组比较差异有统计学意义（ P ＜0.05）。结论角膜塑形镜矫治青少年近视疗效确切，能有效的改善患者的视功能，控制近视的发展，值得推广应用。%Objective To investigate the role of orthokeratology in the treatment of adolescent myopia .Methods A total of 78 adolescent myopia patients (156 eyes) were continuously enrolled from 2011 September to 2012 December and were randomly prescribed with either glasses (group A) or orthokeratology (group B).Visual acuity, refraction, and cor-neal curvature were compared between the two groups .Results After 1 year, visual acuity was better in patients treated with orthokeratology than in patients wearing glasses .Refractive error was also significantly smaller in patients wearing or-thokeratology ( P <0.05).Corneal curvature decreased in patients wearing orthokeratology , whereas it increased in pa-tients wearing glasses, and there was a significant difference between the two groups ( P <0.05).Conclusion Orthokera-tology is an effective treatment for juvenile myopia .It improves the visual function and delays the development of myopia in adolescents .
  • 摘要：Objective To explore the effects of psychological intervention on anxiety , depression and intraocular pressure in patients with primary angle closure glaucoma ( PACG) ,and to explore the exact way of psychological intervention on PACG.Methods Fort-eight patients were divided into two groups randomly .There are no difference in the general situ-ation, medication, surgical Methods, while the intervention group was given psychological intervention .The value of Ham-ilton Anxiety Scale and Depression Scale were detected respectively at the time of admission , the night before surgery ,one day after surgery and discharge .Intraocular pressure were measured every other day after surgery .Data are compared using t test within groups as well as between groups .Results There are no difference between two groups at the time of admis-sion.And the value of Hamilton Anxiety Scale and Depression Scale are significantly lower in intervention group than in control group at all time points(all P <0.05).Intraocular Pressure is significantly lower in intervention group than in con-trol group at the night before surgery and the day of discharge ( P =0.032, P =0.015,respectively).Conclusion Psy-chological intervention is helpful in relieving anxiety and depression and maintaining stable postoperative intraocular pres -sure before and after surgery .%目的：探讨心理干预对原发性闭角型青光眼（ PACG）患者焦虑、抑郁及眼内压的影响，探索将心理干预应用于PACG辅助治疗的具体方法。方法将48例PACG患者随机分为两组，除干预组给予心理干预及放松治疗外，其他术前准备、手术方式均相同。分别于入院时、术前1d晚上、术后1d和出院时检测汉密尔顿焦虑量表及抑郁量表评分，隔日测量眼内压，t检验分析组内及组间差异。结果两组入院时焦虑、抑郁评分及眼内压比较差异无显著性，在术前1 d，术后1 d及出院前干预组和对照组的焦虑值相比分别是24.85±4.22 vs 36.82±3.76（ P＜0.01），24.23±4.73 vs 37.82±3.23（ P ＜0.01），22.27±4.16 vs 25.68±3.64（ P ＜0.01），干预组明显低于对照组，差异有显著性；抑郁值相比分别是27.58±3.73 vs 29.86±4.35（ P ＝0.02），27.62±4.59 vs 30．45±4.77（ P ＝0.02），23.62±3.56 vs 26.5±3.6（ P ＜0.01），干预组明显低于对照组，差异有显著性；干预组的眼内压仅在术前1 d和出院前明显低于对照组，分别是31.27±7.30 vs 34.95±6.00（ P ＝0.032），18.23±2.32 vs 19.68±2.12（ P ＝0.015），差异有显著性。结论心理干预有助于缓解术前和术后的焦虑及抑郁情绪，维持术后平稳的眼内压。
  • 摘要：目的：建立豚鼠形觉剥夺超高度近视模型并观察其后极部各层组织的病理组织学变化。方法2周龄三色豚鼠分为形觉剥夺组（12只）和非形觉剥夺对照组（8只），于形觉剥夺前，形觉剥夺后4、6、10、14周分别对各组进行检影和眼轴性参数测量。通过病理组织学光镜检查分析形觉剥夺14周后各组视网膜、脉络膜和巩膜厚度及其形态学的变化。结果豚鼠形觉剥夺后随时间延长近视度数逐渐增高，10周后可达-10.00 D以上的超高度近视，14周后近视度数更高、个别个体可达-20.00 D。眼轴性参数相应延长。形觉剥夺超高度近视眼视网膜、脉络膜和巩膜较对照组均明显变薄并有病理性改变。结论应用遮盖法对豚鼠施行长期单眼形觉剥夺会形成超高度近视，10周后可达-10.00 D以上，超高度近视眼巩膜、脉络膜和视网膜明显变薄，脉络膜和巩膜结构发生紊乱。视网膜结构中感光细胞层变薄最为明显，推测其对超高度近视的发生起重要作用。%Objective To establish an animal model of form-deprived super-high myopia in guinea pigs and to in-vestigate the fundus histopathological changes .Methods Twenty 2-week-old guinea pigs were randomized into form-de-prived group ( n =12) and control group ( n =8).Refraction and axial length were measured before form deprivation , and at 4, 6, 10 and 14 weeks, respectively.The thickness and morphological changes of retina , choroid and sclera were examined with light microscope after 14 weeks.Results The degree of myopia gradually increased after form deprivation , reached -10.00 D after 10 weeks and exceeded -20.00 D after 14 weeks.Axial length increased accordingly .The reti-na, choroid and sclera were obviously thinner with characteristic pathological changes in form -deprived group than those in control group.Conclusion Super-high myopia in guinea pigs could be successfully induced by long-term monocular form deprivation, reaching more than -10.00 D after 10 weeks.The sclera, choroid and retina in super-high myopia eyes be-came much thinner with characteristic structural changes in sclera and choroid .The significantly thinning of photoreceptor layer in retina might play an important role in super-high myopia .
  • 摘要：Glucocorticoids , a kind of steroid hormones , are known for its potent anti-inflammatory and immunoreg-ulatory effects .Glucocorticoids have been widely used to suppress inflammatory process and to treat many autoimmune dis -orders.The use of glucocorticoids in orbital diseases mainly centers on the treatment for thyroid ophthalmopathy , orbital pseudotumor , and benign lymphoepithelial lesion of lacrimal glands .We reviewed the progress in researches regarding the application of glucocorticoids in orbital diseases .%糖皮质激素是类固醇激素的一种，具有强大的抗炎和免疫调节的作用，已广泛应用于临床多种炎症和免疫性疾病的治疗中。糖皮质激素在眼眶病中的应用主要体现在眼眶炎症和免疫相关性疾病如甲状腺相关眼病、特发性眼眶炎性假瘤和泪腺良性淋巴上皮病变等的治疗上。对糖皮质激素在眼眶病的应用及研究进展进行综述。
  • 摘要：目的：分析病理性近视（PM）黄斑出血的荧光素眼底血管造影（FFA）、吲哚青绿血管造影（ICGA）及相干光断层扫描（OCT）的影像学特征及临床意义。方法对病理性近视黄斑出血28例（31只眼）进行FFA、ICGA及OCT检查，并对比分析其检查图像。结果单纯型出血15只眼（48.4％），FFA表现：出血部位遮蔽荧光，其中8只眼（53.5％）可见漆样裂纹透见荧光；ICGA表现：造影期间出血部位为淡的低荧光，晚期均可见漆样裂纹性条状低荧光；OCT表现：9只眼（60％）在神经上皮层下和4只眼（26.7％）在色素上皮（ RPE）下可见中高反射光团，周围神经上皮无水肿增厚，其下脉络膜光带连续，其中2只眼（13.3％）OCT无明显改变；新生血管（CNV）型出血16只眼（51.6％），FFA 表现：14只眼（87.5％）为典型性 CNV，2只眼（12.5％）为隐匿性 CNV；ICGA 表现：14只眼（87.5％）为焦点状CNV，无明显染料渗漏，2只眼（12.5％）未见CNV改变；OCT表现：14只眼（87.5％）为RPE光带断裂，RPE上梭形或类圆形中、高反射光团，2只眼（12.5％）为RPE层断裂伴不规则增厚中高反射信号，神经上皮层均增厚水肿。结论病理性近视黄斑出血分为单纯型和新生血管型，新生血管多表现为典型CNV，不同类型的出血其FFA、ICGA、OCT的改变各具特征，合理选择检查方法可提高诊断率，节省费用。%Objective To investigate the morphological characteristics of pathological myopia using fundus fluores -cein angiography ( FFA) , indocyanine green angiography ( ICGA) and optical coherence tomography ( OCT) .Methods We studied 28 cases (31 eyes) of pathological myopia with macular hemorrhage .FFA, ICGA, and OCT examinations were performed to characterize the morphological changes in these patients .Results Uncomplicated macular hemorrhage was i-dentified in 15 eyes (48.4%).Among these eyes, FFA showed masked fluorescein in the bleeding region .Striated bands of fluorescein could be observed in 8 eyes (53.5%).ICGA showed similar masks at initial phase and fluorescein bands at later phases.OCT revealed high reflection in neurosensory retina (9 eyes, 60%) or in RPE (4 eyes, 26.7%).There was no retina edema.Choroid appeared to be continuous .In 2 eyes, OCT were completely normal.Another group of eyes ex-hibited choroidal neovascularization (CNV;n=16, 51.6%).FFA identified overt CNV in 14 eyes (87.5%) and occult CNV in 2 eyes (12.5%), while ICGA detected scattered CNV in 14 eyes (87.5%) and in two eyes there was no fluores-cein leakage .OCT showed discontinuation and spindle or round shaped high reflection within RPE in 14 eyes.In 2 other eyes, RPE discontinuation was also found along with irregular thickened RPE and neurosensory retina edema .Conclusion Pathologicsl myopia can present with two different types of pathological changes , uncomplicated macular hemorrhage and choroidal neovascularization .Different morphological characters can be identified through FFA , ICGA and OCT examina-tions.
  • 摘要：目的：观察特发性黄斑前膜的频域相干光断层扫描（OCT）特征以及与患者视力的相互关系。方法收集2010年10月至2013年6月在我院门诊确诊的特发性黄斑前膜患者的临床资料，共182例（212只眼），年龄35～88岁，平均（66.08±9.25）岁，所有患者均进行最佳矫正视力、眼底和OCT检查。根据OCT检查所见对黄斑前膜进行分类，分析中心凹形态及黄斑部视网膜神经上皮层体积与视力的关系，采用SPSS13．0软件对患者的各项OCT检查结果进行统计学分析。结果（1）特发性黄斑前膜的OCT图像特征表现为视网膜神经上皮层表面厚薄不一的高反光带，部分与视网膜内表面完全紧密粘连或分离。黄斑前膜的中心凹形态改变有5种表现，中心凹正常型33只眼（15.7％），伴有板层裂孔17只眼（8.0％），伴有假性黄斑裂孔16只眼（7.5％），伴有弥漫水肿121只眼（57.0％），伴有囊样水肿25只眼（11.8％）。（2）中心凹正常组与其它中心凹形态组的视网膜神经上皮层体积比较，差异有统计学意义（P＜0.05）。（3）黄斑部视网膜神经上皮层体积与视力呈负相关（r＝0.029，P＜0.01）。结论黄斑前膜患者视力与黄斑部视网膜神经上皮层体积具有负相关性，0CT作为黄斑前膜可靠的诊断方法，在临床上可以减少漏诊，并可以为手术提供更详细的信息。%Objective To observe morphological changes in macular idiopathic epiretinal membrane ( IERM) u-sing Fourier-domain optical coherence tomography (FD-OCT), and to correlate those morphological changes to patients ’ best corrected visual acuity (BCVA).Methods Records of 182 IMEM patients (212 eyes) who were diagnosed in our hospital between October 2010 and June 2013 were reviewed .Results of fundus examination , macular OCT scan , and visual acuity were collected .Foveal morphology and macular volume were correlated to visual acuity .Results Macular epiretinal membrane was visible on OCT images as a high reflective band with varied thickness .The IERM may partially connect to or separate from the inner surface of the retina .Foveal morphological changes can be categorized into 5 types, namely, lami-nar macular holes ( LMH ) , macular pseudoholes ( MPH ) , cystoid macular edema ( CME ) , diffuse macular edema (DME), and normal according to the findings of OCT .LMH were found in 17 eyes (8.0%), MPH in 16 eyes (7.5%), CME in 25 eyes ( 11.8%) , DME in 121 eyes ( 57.0%) , and normal in 33 eyes ( 15.7%) .The macular volume was 9.56 ±1.84 mm3, and there was a significant difference between normal and all other patients .Negative correlation be-tween BCVA and macular volume ( r =0.029, P <0.01) was noted.Conclusion OCT is a reliable method to diagnose ERM.It can reduce the risk of missed diagnose and provide more detailed information before surgery .
  • 摘要：Objective To observe the changes of corneal endothelial cell density in angle closure glaucoma pa -tients after combined cataract phacoemulsification and trabeculectomy .Methods Sixty-one patients with cataract and an-gle closure glaucoma ( 61 eyes ) received phacoemulsification , intraocular lens implantation and trabeculectomy .Central corneal endothelial cell density was measured before surgery and at 3 months, 6 months and 12 months after surgery.Re-sults Average preoperative endothelial cell density was 2209 ±343/mm2.Endothelial cell density decreased to 1665 ± 487/mm2 , 1636 ±492/mm2 , and 1635 ±509/mm2 at 3 months, 6 months and 12 months after the surgery , representing a reduction of 24.63%, 25.95%, and 25.98%, respectively.The reduction of endothelial cell density was significant ( P<0.05), and there were no signs of improvement during the follow-up period, suggesting that the endothelial cell loss is permanent .Conclusion It is important to assess the corneal endothelial cells in angle closure glaucoma patients before surgery treatments in order to prevent corneal endothelial dysfunction .%目的：观察闭角型青光眼合并白内障行超声乳化人工晶状体植入联合小梁切除手术前后角膜内皮细胞的变化。方法对闭角型青光眼合并白内障患者61例（61只眼）行超声乳化人工晶状体植入联合小梁切除术，分别于术前及术后3、6、12个月测量角膜中央区内皮细胞密度进行分析比较。结果术前角膜中央区平均内皮细胞密度为（2209±343）个/mm2，术后3、6、12个月角膜中央区平均内皮细胞密度分别为（1665±487）个/mm2、（1636±492）个/mm2、（1635±509）个/mm2，与术前比较丢失率为24.63％、25.95％、25.98％，各随访期角膜中央区平均内皮细胞密度与术前比较明显下降，差异具有统计学意义（ P ＜0.05），术后3、6、12个月角膜中央区平均内皮细胞密度虽然有所下降，但差异无统计学意义（ P ＞0.05）。结论对闭角型青光眼合并白内障行超声乳化人工晶状体植入联合小梁切除术术后角膜内皮功能失代偿的预测评估至关重要。
  • 摘要：由石一宁、方严教授主编的《中国儿童青少年近视形成机制以及预测与防控》一书已陕西科学技术出版社出版。该书以全新的视角和独特的构思框架,直视近视,特别是中国儿童青少年近视。因为,近视问题作为小眼科专科的小专业——眼视光学的一部分,已从单纯的临床医学问题演变为备受人们高度关注的社会问题、
  • 摘要：Objective Avastin (bevacizumab) intravitreal injections are widely used in the treatment of diabeticretinopathy.This study was to determine the serum concentrations of vascular endothelial growth factor (VEGF) in patientswith diabetic retinopathy after intravitreal injection of bevacizumab .Methods Twenty-two patients (22 eyes) diagnosedwith active proliferative diabetic retinopathy were enrolled in this study .Bevacizumab 1.25 mg was administered intravitrealy.Serum VEGF concentration was measured by ELISA on the day of the bevacizumab administration and on day 1, day7, and day 28.Results Twenty-four hours after bevacizumab administration, serum VEGF concentration significantly decreasedfrom baseline in all patients, and reached a nadir at the 7th day.VEGF level rose again at 28 days after the treatmentbut did not reached pre-treatment level in most of patients.Conclusion Decreased serum VEGF level after single intravitrealinjection of bevacizumab indicated that bevacizumab entered the circulation and maintained a therapeutic level fora long time.Therefore, physicians should be cautious about systemic side effects and side effects in the fellow eye .%目的：研究玻璃体腔注射贝伐单抗Avastin后增生性糖尿病视网膜病变（ PDR）患者血清中血管内皮细胞生长因子（ VEGF）的变化。方法收集玻璃体腔注射Avastin后PDR患者血清样本（注射前当天，注射后1 d，注射后7 d，注射后28 d），并以注射前当天的血清样本为基准值作为对照，用ELISA 方法测定血清中VEGF的含量。结果玻璃体腔注射Avastin术后，所有样本血清中VEGF含量都降低，降低幅度在术后7 d达到最大峰值，术后28 d VEGF有所上升，但仍未达到术前水平。结论一次玻璃体腔注射Avastin术后，血清中VEGF含量降低并且维持相当时间，说明Avastin进入到血液循环中，因此有必要密切关注Avastin玻璃体腔注射后的系统性影响和对未注射眼的影响。
  • 摘要：Objective To observe and analyze the relationship between diabetic retinopathy ( DR), C-reactive protein ( CRP) and metabolic syndrome ( MS) .Methods Totally 183 patients with type 2 diabetes mellitus were included in this study.Subjects were divided into the two groups according to whether DR presented (observation group, n =101) or did not present (control group, n =82).Serum CRP level, routine metabolism indexes, and the prevalence of MS in the two groups were compared.Results Patients in the observation group, i.e., presented with DR, showed significantly higher levels of serum biomarkers including CRP , HbA1c, triglyceride and total cholesterol ( P <0.05).Not surprising-ly, the prevalence of MS and dyslipidemia were also higher in the patients with DR ( P <0.05).Furthermore, CRP and HbA1c levels were significantly higher in patients with more advanced DR than in patients with milder DR ( P <0.05). Multivariate logistic regression analysis showed that the triglyceride (OR=1.520) and CRP (OR=2.376) were positively correlated with the incidence of DR ( P <0.05).Conclusion Increased HbA1c and presence of MS or dyslipidemia may be the risk factors of DR.The high CRP and high triglyceride levels are independent risk factors of DR .CRP and HbA1c may be correlated with the severity of DR .Clinicians should employ early interventions among patients with these high risk factors in order to improve the outcomes of DR .%目的：观察和分析2型糖尿病患者糖尿病视网膜病变（ DR）的发生与C-反应蛋白（ CRP）水平和代谢综合征（ MS）的关系。方法选取183例2糖尿病患者作为观察对象，根据是否并发有DR将其分为观察组和对照组，101例并发有DR的患者列为观察组，82例未并发DR的患者列为观察组，对两组患者的血清CRP水平、各项常规代谢指标、MS患病率的情况进行观察和比较。结果观察组的血清CRP水平、糖化血红蛋白（ HbAlc ）水平、甘油三酯（TG）水平、总胆固醇（TC）水平和MS患病率均显著高于对照组（ P ＜0.05），观察组患者脂代谢紊乱的患病率显著高于对照组（ P ＜0.05）；各期DR患者的CRP水平和HbAlc水平的差异均有显著性（ P ＜0.05），且随着DR程度的加重，CRP水平和HbAlc水平呈上升的趋势；Logistic多元回归分析显示，患者的TG水平（ OR＝1.520）和CRP水平（OR＝2.376）均与DR的发病呈正相关关系（ P ＜0.05）。结论 HbAlc水平、MS及其中的脂质代谢异常可能是DR发病的危险因素，高CRP水平和高TG水平是DR发病的独立危险因素，且CRP水平、HbAlc水平可能与DR的严重程度具有相关性，临床医生应根据患者的高危因素情况予以早期干预，以改善DR患者的预后。
  • 摘要：由王雁教授、赵堪兴教授为主编,国内、外视觉领域著名专家和知名学者参与共同编写的《波前像差与临床视觉矫正》一书已由人民卫生出版社正式出版。目前视觉科学领域发展较快,许多新的视觉理论和知识已渗透到眼科各个专业中,在我国目前尚缺少一本系统介绍人眼视觉光学基础及波前像差等临床应用的专业书籍。本书从临床角度较全面地阐述了现代光学基本理论及原理,包括眼球光学结构、视觉成像的光学基础等内容,同时结合临床对波前像差基本概念、
  • 摘要：Objective To investigate the effects of fluvastatin on expression of Smad-3 in alkali-burned cornea in rats.Methods Alkali corneal burns were induced to right eye in 24 SD rats using 1 mol/L NaOH.Animals were then randomly received one of 3 treatments ( n =8 for each group): normal saline, fluvastatin, or dexamethasone.In 1~7 days, corneal neovascularization was examined with slit-lamp, and pathological changes were evaluated with HE staining . The expression of Smad-3 was detected with immunohistochemical staining .Results At 7 days after corneal burns , corne-al neovascularization was significantly less severe in rats treated with fluvastatin than in rats treated with normal saline ( P<0.05).Histopathological examines showed less neovascularization and inflammatory cells infiltration , and more orderly corneal structure .Immunohistochemical staining showed that the expression of Smad-3 was significantly lower in fluvastatin treated rats .Conclusion Fluvastatin can reduce the severity of corneal neovascularization , and the mechanism may be re-lated to the down-regulated expression of Smad-3.%目的：探讨氟伐他汀对大鼠角膜碱烧伤后Smad-3表达的影响。方法24只SD大鼠随机分为3组：生理盐水组、氟伐他汀组和地塞米松组，每组8只，用1mol/L的NaOH烧伤大鼠右眼，生理盐水组、氟伐他汀组和地塞米松组分别以生理盐水、氟伐他汀和1g/L地塞米松点眼。烧伤后1～7 d用裂隙灯观察角膜新生血管的生长情况，HE染色观察角膜组织病理学改变，免疫组化观察Smad-3的表达情况。结果烧伤后第7天，氟伐他汀组的角膜新生血管生长密度显著低于生理盐水组，差异有统计学意义， P ＜0．05。组织病理学检查结果提示，氟伐他汀组与生理盐水组相比，新生血管的形成明显减少，管腔小且稀疏，周围炎症细胞浸润明显减少，角膜组织结构明显整齐。免疫组化结果显示氟伐他汀组的Smad-3的表达情况显著降低。结论氟伐他汀能通过下调Smad-3的表达，来减轻大鼠角膜碱烧伤后新生血管的生成。
  • 摘要：（三）多层面诊断： 是综合分析五步法的第四步。 近视的诊断需从6个层面全面诊断近视,包括屈光成分、屈光程度、双眼视功能、近视性质、近视进展速度以及近视并发症。见附录5假期近视防控诊断流程（六层面）。
  • 摘要：目的：应用眼前段相干光断层成像（ AS-OCT）检测改良黏小管切开术（ VCO）术后手术区域组织结构及滤道，以讨论改良黏小管切开术降眼压的机制。方法横断面研究。研究对象为术后从3～72个月的38例（55只眼）开角型青光眼，均为术前药物控制不良的开角型青光眼。11只眼（20％）因眼压高行Nd：YAG激光房角穿孔术。同时进行视力、眼压、裂隙灯、眼底和AS-OCT检查。 AS-OCT的检测指标为：①滤过泡形态，②巩膜池的长、宽、高，③脉络膜上腔，④泪河高度。结果患者术后眼压（15.4±4.9） mm Hg较术前（31.0±10．9） mm Hg明显下降，42只眼有弥散的滤泡。 AS-OCT证明了结膜瓣下腔隙的存在，39只眼（70．9％）检测到巩膜池，巩膜池的平均体积为1.09 mm3（0.04～0．203 mm3）。结论 AS-OCT检查证明了改良VCO房水引流的可能机制。扁平弥散的结膜下腔隙证明了持续的滤过，为眼外引流；39只眼（70．9％）存在巩膜池。巩膜池的体积与眼压无关，提示脉络膜上腔可能是主要的房水眼内引流途径。%Objective The aim of this study was to reveal structural and mechanical changes of outflow pathways after modified viscocanalostomy (modified VCO) using anterior segment optical coherence tomography (AS-OCT).Meth-ods Fifty-five eyes of 38 patients with medically uncontrolled open-angle glaucoma received modified VCO .Eleven eyes (20%) also received Nd:YAG laser goniopuncture to further control intraocular pressure ( IOP) .Postoperative follow-up included complete ophthalmic examinations and AS-OCT scan of the filtering site .The following assessments were done with AS-OCT:1) dimensions of subconjunctival filtering bleb;2) volume of intrascleral cavity;3) volume of suprachoroidal space;4) height of tear meniscus .Results Intraocular pressure decreased significantly from 31.0 ±10.9 mmHg to 15.4 ±4.9mmHg.AS-OCT demonstrated a subconjunctival space in forty-two eyes.In 39 eyes (70.9%) an intrascleral cavity was observed.The mean volume of this cavity was 1.09 mm3(0.04-0.203 mm3).Conclusion AS-OCT revealed several possible pathways for aqueous humour drainage after modified VCO .A flat, diffuse subconjunctival space indicated persis-tent drainage.Thirty-nine eyes (70.9%) exhibited a remaining intrascleral cavity , whose volume was unrelated to IOP , suggesting that suprachoroidal outflow may be the main outflow pathway after modified VCO .
  • 摘要：芜湖昭美眼科医院是由一帮眼科医生严格按照安徽省卫生厅二级眼科专科医院规范创建的现代化眼科医院,医院按照国际标准化模式设计,典雅气派、简洁时尚、温馨怡人。经营目标一是为了提高眼科技术水平、更好的做自己喜欢做的事情,二是为了更好地为眼疾患者服务,三是为了实现更多的价值。
  • 摘要：Objective To explore the efficacy of combined limbal stem cell autograft transplantation and photother -apeutic keratectomy (PTK) for treatment of pterygium.Methods Totally 174 patients (192 eyes) who suffered from pte-rygium were enrolled in this study .Patients were randomly assigned to receive either limbal stem cell autograft transplanta-tion alone (group A, n =94) or combined with phototherapeutic keratectomy (group B, n =98).Follow-up was 6 to 24 months.Corneal healing time, scar formation, rate of recurrence, changes in visual acuity, and refraction were evaluated and compared between the two groups .Results Patients in group B, i.e., those who received combined limbal stem cell autograft transplantation and PTK , needed shorter time for cornea healing , showed less scar formation , had better visual a-cuity outcomes, less astigmatism, and smaller recurrence rate.Conclusion Combination of limbal stem cell autograft transplantation and phototherapeutic keratectomy ( PTK) is an effective and safe treatment for pterygium .%目的：探讨自体角膜缘干细胞移植联合准分子激光治疗性角膜切削术（ PTK）治疗翼状胬肉的临床疗效。方法将翼状胬肉患者174例（192只眼）随机分为A组（94只眼），行自体角膜缘干细胞移植术；B组（98只眼），行自体角膜缘干细胞移植联合PTK。术后随访6～24个月，对比观察角膜修复时间、瘢痕形成情况、复发率、术后视力提高、角膜散光变化情况。结果 B组患者早期角膜修复时间、瘢痕形成、术后视力提高、角膜散光减少优于A组，术后复发率B组略低于A组。结论自体角膜缘干细胞移植联合PTK治疗翼状胬肉效果好、恢复快、复发率低，值得推广应用。
  • 摘要：由方严教授、石一宁教授主编的《病理性近视眼眼底改变》一书受国家科学技术学术著作出版基金资助、已由科学技术文献出版社出版。本书全面介绍了近年来国内外对病理性近视眼眼底改变的研究进展。作者结合自己工作中的临床研究资料并系统复习病理性近视眼相关文献,分别从病理性近视眼概论、病理性近视眼眼底改变的分类及演变、豹纹状眼底、后葡萄肿、视盘改变、视网膜脉络膜改变、黄斑改变（综合）、周边眼底改变、玻璃体后脱离、
  • 摘要：Objective To describe the treatment of canaliculitis with Canalicular hemisection combining with intu-bation under microscopy and evaluate the surgical effect .Methods Clinical records of 24 patients diagnosed with primary canaliculitis and treated at Shantou eye center , between January 2011 and June 2013, were reviewed.All patients received the same microscopy surgery:(1)A paralleling eyelid incision, 3mm below the margin, was performed to expose the bulgy canaliculus.(2)Incising the canaliculus along its full extent .The contents of canaliculus were curetted , and purulent mate-rial drained.(3)Two ends of silicone tubing are threaded via the superior and inferior puncta , through the lacrimal sac down to the nose, where they are tied.(4) The dilated canaliculus was narrowed by Hemisection and wound was sutured with 8-0 vicryl.The follow-up time was 6 months.Results During operation, abcess was revealed within the expanded stomach-like canaliculus.The suture of the skin was removed 1 week after operation and the tubing was left for 3 months. After 6 months follow-up period, 22 patients had open lacrimal drainage system on syringing (91.7%).2 patients recur-rence with canalicular obstruction .The tubing in one of the two patients fell off 1 week after operation .The purulent dis-charge and swelling eyelid were completely resolved in all the patients with open puncta .Conclusion Canalicular hemisec-tion with intubation is an effective way to treat canaliculitis and reconstruct the canaliculus , especially for inferior canalicul-itis.%目的：评价显微镜下行泪小管部分管壁切除联合硅胶软管植入重建泪小管的手术效果。方法收集2011年1月到2013年6月我院住院的泪小管炎患者24例。在显微镜下手术：（1）距内眦睑缘约3 mm平行切开眼睑皮肤，暴露膨大脓肿的泪小管；（2）水平切开泪小管，清除泪小管内脓性分泌物、结石和肉芽组织；（3）分别从上下泪小点植入软性硅胶管经泪囊、鼻泪管一同出鼻腔；（4）切除多余扩张的水平部分泪小管前壁，用8-0可吸收缝线间断缝合残余的泪小管后壁，包绕硅胶管，重建泪小管。术后观察6个月。结果术中见泪小管膨大脓肿，像人体“胃”的结构。术后1周拆除皮肤缝线，3个月取出泪道引流管。术后6个月，22例泪道冲洗通.，占91.7％；2例泪小管再阻塞，其中1例为术后1周泪道植入管脱落。全部患者均无流脓，泪小管无红肿，泪小点开放，睑缘整齐。结论泪小管水平部分管壁切除联合硅胶软管植入，重建泪小管，恢复泪道引流功能，疗效好，是治疗泪小管炎尤其是下泪小管炎较理想的手术方法。
  • 摘要：Objective To explore the Ex-PRESS glaucoma drainage device implantation combined mitomycin C in the treatment of refractory glaucoma .Methods The application of the Ex-PRESS glaucoma drainage device implantation combined mitomycin C treatment of 45 cases of refractory glaucoma .Results After the Ex-PRESS glaucoma drainage de-vice implantation combined mitomycin C ,intraocular pressure control , maintain good filtration , small damage to eyesight . Conclusion The Ex-PRESS glaucoma drainage device implantation combined mitomycin C has a very good therapeutic effect on refractory glaucoma .%目的：探讨Ex-PRESS青光眼引流器植入术联合丝裂霉素C应用治疗难治性青光眼的疗效。方法应用Ex-PRESS青光眼引流器植入术联合丝裂霉素C治疗45例难治性青光眼。结果行Ex-PRESS青光眼引流器植入术联合丝裂霉素C后眼压控制，滤过维持好，视力损伤轻。结论 Ex-PRESS青光眼引流器植入术联合丝裂霉素C对难治性青光眼有着很好的治疗作用。
  • 摘要：泪囊鼻腔吻合术由于传统手术方法费时长,难度大,易出血,影响了手术的成功率。作者对传统的手术方法进行改良,植入泪囊鼻腔引流支架,简化步骤,缩短手术时间,减少患者的痛苦和紧张情绪,疗效确切。于2010年3月至2013年3月,对426例（567只眼）慢性泪囊炎患者,采用改良泪囊鼻腔吻合术联合泪囊鼻腔引流支架植入,通过随访观察,疗效满意。现报告如下。
  • 摘要：目的：探讨儿童视网膜色素变性在诊断和治疗方面的临床特点。方法将符合准入标准的27名14岁以下视网膜色素变性患者在进行视野检查后，分为有家族史患者组和无家族史患者组，用二十二碳六烯酸胶囊、β-胡萝卜素胶囊、血脂康胶囊治疗1年，以中心视力和视野平均缺损敏感度（ MD）作为疗效的观察指标。观察总结儿童视网膜色素变性患者在诊断和治疗中的临床特点。结果归纳儿童视网膜色素变性患者的临床特点有：（1）他人发现患者患病；（2）全自动视野检测是首选的检查手段；（3）可能会有极少数患者被误诊；（4）无家族史患者比有家族史患者的治疗效果好。结论儿童视网膜色素变性患者具有4个临床特点。%Objective To investigate the clinical presentation and therapeuticalmethodsof retinitis pigmentosa (RP) in children.Methods Twenty seven children younger than 14 years old who were diagnosed with RP and met the study criteria were enrolled .Patients received Humphrey automatic perimeter examination and were assigned into 2 groups according to the hereditary pattern of the RP (hereditary or non-hereditary).All patients received treatments with docosa-hexaenoic acid, vitamin A palmitate, zeaxanthin, monacolin K and selenium for one year .Visual acuity (VS) and mean deviation ( MD) of visual field were recorded in the beginning and at the end of study .Results The chief complaint of RP were impaired nocturnal vision , and mainly were reported by parents rather than patients themselves .Some asymptomatic patients were brought to clinic because of family history .After one year treatment , mean deficits in perimetry increased in non-hereditary patients ( P <0.05) while were not changed in hereditary patients .There was no change in central visual acuity in both groups .Conclusion Symptoms of RP, e.g., impaired nocturnal vision , were oftennoticed by parents or siblings rather than patients themselves .Automatic perimeter examination is a preferred screening method for RP .Dspite that, mis-diagnosis could still happen to some patients .Treatment outcomeswere generally better in non-hereditary patients than in hereditary patients .
  • 摘要：患者女性,42岁。因＂全身散发皮肤褐色斑及增生肿物数十年＂入院。患者幼时即发现全身皮肤散发咖啡斑,全身数十个大小不一增生肿物,随年龄增长,咖啡斑及肿块均逐渐增大,无明显疼痛,瘙痒等不适。自述其父亲及其女儿均有类似皮肤表现。门诊拟＂神经纤维瘤＂收入院。查体：全身皮肤散发咖啡斑,胸背部、四肢数十个大小不一的类圆形增生肿物,质软（见图1）。眼科检查：视力：右眼0.8,左眼1.0。
  • 摘要：由方严教授、石一宁教授主编的《病理性近视眼眼底改变》一书受国家科学技术学术著作出版基金资助、已由科学技术文献出版社出版。本书全面介绍了近年来国内外对病理性近视眼眼底改变的研究进展。
  • 摘要：芜湖昭美眼科医院是由一帮眼科医生严格按照安徽省卫生厅二级眼科专科医院规范创建的现代化眼科医院,医院按照国际标准化模式设计,典雅气派、简洁时尚、温馨怡人。经营目标一是为了提高眼科技术水平、更好的做自己喜欢做的事情,二是为了更好地为眼疾患者服务,三是为了实现更多的价值。芜湖昭美眼科医院配置了美国ALCON公司LenSx飞秒白内障手术系统、瑞士ZIEMER公司LDV飞秒激光、
  • 摘要：为促进眼科学专业领域的国际交流,使国内医师能够阅读到优秀的眼科学海外专著,中华国际医学交流基金会海外优秀医学专著引进项目编辑部于2012年8月组织出版了《眼科疾病的发病机制与治疗》一书。

    临床眼科杂志的期刊信息

    • 创刊时间：1993
    • 地区：CN
    • 语言：中文
    • 热门主题：安徽医科大学;安徽眼科研究所
    • 学科分类：

    临床眼科杂志的获奖情况

    临床眼科杂志的收录情况

    • • 日本科学技术振兴机构数据库
    • • 中国科技核心期刊

    临床眼科杂志的投稿信息

    • 投稿方式：邮箱投稿并邮寄纸质稿
    • 通讯地址：合肥市绩溪路218号
    • 邮编：230022
    • 联系电话：0551-62923182 62923235
    • 邮箱：lcykzz@sina.com;hnfy@sohu.com
    • 期刊栏目：临床研究；实验研究；论著简报；病例报告；综述与讲座
    免费订阅本刊

    客服邮箱：kefu@zhangqiaokeyan.com

    京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有 出版物经营许可证

    • 客服微信

    • 服务号