Direct-write patterning of nanostructured sensory waveguides for integrated optical bioimaging applications

机译：用于集成光学生物成像应用的纳米结构传感波导的直接写入图案

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We report the development of a novel methodology for patterning of nanostructured sensory materials using multidimensional microstructured support platforms for optical bioimaging applications. Specifically, the support platforms are fabricated using direct-write technique and sol-gel derived xerogel thin-films to form the sensor materials. This creates a simple and versatile method for developing complex 3-D microstructures that have the combined capabilities of biochemical sensing, microfluidic sample distribution for sensor arrays, and direct integration with Complimentary Metal-Oxide Semiconductor (CMOS) Integrated Circuits (ICs) used for sensor signal detection and processing. More importantly, this methodology would enable the development of large-scale arrayed sensing platforms for applications in cell-culture analysis and tissue imaging. The configuration and fabrication of the proposed microstructures, which consist of planar ridge and hollow waveguides, will be described in detail. As a prototype implementation, we demonstrate direct-write ridge waveguide support structures coated with luminophore-doped xerogels that are responsive to gaseous oxygen (O_2) concentration.

机译：我们报告了一种新型方法的发展，该方法用于使用光学生物成像应用的多维微结构化支撑平台对纳米结构感官材料进行图案化。具体而言，使用直接写入技术和溶胶凝胶衍生的干凝胶薄膜制造支撑平台，以形成传感器材料。这创建了一种简单而通用的方法来开发复杂的3-D微结构，这些结构具有生化传感，传感器阵列的微流体样品分配以及与用于传感器的互补金属氧化物半导体（CMOS）集成电路（IC）直接集成的综合功能信号检测和处理。更重要的是，这种方法将能够开发用于细胞培养分析和组织成像的大规模阵列传感平台。将详细描述所提出的由平面脊和中空波导组成的微结构的构造和制造。作为原型实现，我们演示了直接写入的脊形波导支撑结构，该结构涂覆有对气态氧（O_2）浓度有响应的掺杂发光体的干凝胶。

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来源
《Conference on Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications; 20080121-23; San Jose,CA(US)》|2008年|P.iviii|共2页
会议地点 San JoseCA(US)
作者
Mohamad Hajj-Hassan; Timothy Gonzalez; Hagop Djeghelian; Ebrahim Ghafar-Zadeh; Daniel Therriault; Vamsy Chodavarapu; Mark Andrews;
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作者单位

Department of Electrical and Computer Engineering, McGill University, Montreal, QC, Canada H3A 2A7;

Department of Chemistry, McGill University, Montreal, QC, Canada H3A 2A7;

Department of Mechanical Engineering, Ecole Polytechnique de Montreal, Montreal, Q;

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原文格式 PDF
正文语种 eng
中图分类医用物理学;
关键词
direct-write technology; xerogels; CMOS; biosensors; sensor microsystem; waveguide microstructures; optical sensors; fluorescence; oxygen sensors; polymer waveguides;

机译：直写技术;干凝胶; CMOS;生物传感器;传感器微系统;波导微结构;光学传感器;荧光;氧传感器;聚合物波导;

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2. Preparation and optical properties of sol-gel derived photo-patternable organic-inorganic hybrid films for optical waveguide applications [J] . C.Y. Jia, Wenxiu Que, W.G. Liu Thin Solid Films . 2009,第1期

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3. Photonic applications of one-dimensional organic single-crystalline nanostructures: optical waveguides and optically pumped lasers [J] . Qiu Hong Cui, Yong Sheng Zhao, Jiannian Yao Journal of Materials Chemistry: An Interdisciplinary Journal dealing with Synthesis, Structures, Properties and Applications of Materials, Particulary Those Associated with Advanced Technology . 2012,第10期

机译：一维有机单晶纳米结构的光子应用：光波导和光泵浦激光器
4. Direct-write patterning of nanostructured sensory waveguides for integrated optical bioimaging applications [C] . Mohamad Hajj-Hassan, Timothy Gonzalez, Hagop Djeghelian, Conference on Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications . 2008

机译：用于集成光学生物分析应用的纳米结构感觉波导的直接写图案化
5. Integrated silicon waveguides and specialty optical fibers for optical communications system applications. [D] . Yue, Yang. 2012

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6. Editorial: Fluorescent Carbon-Based Nanostructures for Bioimaging Applications [O] . Timur Sh. Atabaev, Dong-Wook Han 2020

机译：编辑：荧光碳基纳米结构用于生物体积应用
7. Microfabrication with femtosecond laser processing : (A) laser ablation of ferrous alloys, (B) direct-write embedded optical waveguides and integrated optics in bulk glasses. [O] . Guo, Junpeng, McDaniel, Karen Lynn, Palmer, Jeremy Andrew, 2004

机译：采用飞秒激光加工的微细加工：（a）铁合金的激光烧蚀，（B）直接写入嵌入式光波导和大块玻璃中的集成光学器件。
8. Microfabrication with femtosecond laser processing : (A) laser ablation of ferrous alloys, (B) direct-write embedded optical waveguides and integrated optics in bulk glasses. [R] . 2004

机译：采用飞秒激光加工的微细加工：（a）铁合金的激光烧蚀，（B）直接写入嵌入式光波导和大块玻璃中的集成光学器件。

Direct-write patterning of nanostructured sensory waveguides for integrated optical bioimaging applications

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