Direct-write patterning of nanostructured sensory waveguides for integrated optical bioimaging applications

机译：用于集成光学生物分析应用的纳米结构感觉波导的直接写图案化

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We report the development of a novel methodology for patterning of nanostructured sensory materials using multidimensional microstructured support platforms for optical bioimaging applications. Specifically, the support platforms are fabricated using direct-write technique and sol-gel derived xerogel thin-films to form the sensor materials. This creates a simple and versatile method for developing complex 3-D microstructures that have the combined capabilities of biochemical sensing, microfluidic sample distribution for sensor arrays, and direct integration with Complimentary Metal-Oxide Semiconductor (CMOS) Integrated Circuits (ICs) used for sensor signal detection and processing. More importantly, this methodology would enable the development of large-scale arrayed sensing platforms for applications in cell-culture analysis and tissue imaging. The configuration and fabrication of the proposed microstructures, which consist of planar ridge and hollow waveguides, will be described in detail. As a prototype implementation, we demonstrate direct-write ridge waveguide support structures coated with luminophore-doped xerogels that are responsive to gaseous oxygen (O_2) concentration.

机译：我们报告了使用用于光学生物分析应用的多维微结构支持平台的多维微结构支持平台进行图案化纳米结构感觉材料的新方法的开发。具体地，使用直接写入技术和溶胶 - 凝胶衍生的Xerogel薄膜制造支持平台以形成传感器材料。这为开发具有生物化学感测的复杂3-D微结构的简单而通用的方法，具有用于传感器阵列的生物化学传感，微流体样本分布的组合能力，以及与用于传感器的互补金属氧化物半导体（CMOS）集成电路（IC）的直接集成信号检测和处理。更重要的是，该方法能够在细胞培养分析和组织成像中发展大规模排列的传感平台。将详细描述由平面脊和中空波导组成的所提出的微结构的配置和制造。作为原型实现，我们展示了涂有激光掺杂荧光体氧化物的直接写入脊波导支撑结构，其响应于气态氧（O_2）浓度。

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《Conference on Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications》|2008年||共2页
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Mohamad Hajj-Hassan; Timothy Gonzalez; Hagop Djeghelian; Ebrahim Ghafar-Zadeh; Daniel Therriault; Vamsy Chodavarapu; Mark Andrews;
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中图分类医用物理学;
关键词
direct-write technology; xerogels; CMOS; biosensors; sensor microsystem; waveguide microstructures; optical sensors; fluorescence; oxygen sensors; polymer waveguides;

机译：直接写入技术;Xerogels;CMOS;生物传感器;传感器微系统;波导微观结构;光学传感器;荧光;氧气传感器;聚合物波导;

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1. Fabrication of fully integrated antiresonant reflecting optical waveguides using the femtosecond laser direct-write technique [J] . Simon Gross, Maider Alberich, Alexander Arriola, Optics Letters . 2013,第11期

机译：使用飞秒激光直接写入技术制造完全集成的反共振反射光波导
2. Preparation and optical properties of sol-gel derived photo-patternable organic-inorganic hybrid films for optical waveguide applications [J] . C.Y. Jia, Wenxiu Que, W.G. Liu Thin Solid Films . 2009,第1期

机译：用于光波导的溶胶-凝胶衍生的可光形成图案的有机-无机杂化膜的制备和光学性质
3. Photonic applications of one-dimensional organic single-crystalline nanostructures: optical waveguides and optically pumped lasers [J] . Qiu Hong Cui, Yong Sheng Zhao, Jiannian Yao Journal of Materials Chemistry: An Interdisciplinary Journal dealing with Synthesis, Structures, Properties and Applications of Materials, Particulary Those Associated with Advanced Technology . 2012,第10期

机译：一维有机单晶纳米结构的光子应用：光波导和光泵浦激光器
4. Direct-write patterning of nanostructured sensory waveguides for integrated optical bioimaging applications [C] . Mohamad Hajj-Hassan, Timothy Gonzalez, Hagop Djeghelian, Conference on Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications; 20080121-23; San Jose,CA(US) . 2008

机译：用于集成光学生物成像应用的纳米结构传感波导的直接写入图案
5. Integrated silicon waveguides and specialty optical fibers for optical communications system applications. [D] . Yue, Yang. 2012

机译：用于光通信系统应用的集成硅波导和专用光纤。
6. Editorial: Fluorescent Carbon-Based Nanostructures for Bioimaging Applications [O] . Timur Sh. Atabaev, Dong-Wook Han 2020

机译：编辑：荧光碳基纳米结构用于生物体积应用
7. Microfabrication with femtosecond laser processing : (A) laser ablation of ferrous alloys, (B) direct-write embedded optical waveguides and integrated optics in bulk glasses. [O] . Guo, Junpeng, McDaniel, Karen Lynn, Palmer, Jeremy Andrew, 2004

机译：采用飞秒激光加工的微细加工：（a）铁合金的激光烧蚀，（B）直接写入嵌入式光波导和大块玻璃中的集成光学器件。
8. Microfabrication with femtosecond laser processing : (A) laser ablation of ferrous alloys, (B) direct-write embedded optical waveguides and integrated optics in bulk glasses. [R] . 2004

机译：采用飞秒激光加工的微细加工：（a）铁合金的激光烧蚀，（B）直接写入嵌入式光波导和大块玻璃中的集成光学器件。

Direct-write patterning of nanostructured sensory waveguides for integrated optical bioimaging applications

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