Fabrication of Silicon Dioxide Nano Array for Bio-mimicking of Molecular Interactions

机译：用于分子相互作用生物模拟的二氧化硅纳米阵列的制备

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We employed atomic force microscopy (AFM) with bias control to fabricate oxided nanopatterns on silicon surface with feature size down to 50nm. The relationship of silicon dioxide nanopatterns against humidity was studied and then the optimal parameter was used to make oxide nanoarry for interaction of biotin and streptavidin. The scanning function of AFM was utilized to verify the different height of biomolecules. According to our experimental results, using nano biochip of silicon dioxide can decrease the monitoring scale to nanometer and can be the nano-platform for monitoring the behavior of biomolecular interaction. We anticipate mimicking the correlation of single molecular behavior and an array of biomolecular behavior to understand the coincidence of them.

机译：我们采用具有偏向控制的原子力显微镜（AFM）在硅表面上制作了特征尺寸低至50nm的氧化纳米图案。研究了二氧化硅纳米图形与湿度的关系，然后采用最佳参数制备了用于生物素与链霉亲和素相互作用的氧化物纳米结构。原子力显微镜的扫描功能被用来验证生物分子的不同高度。根据我们的实验结果，使用二氧化硅的纳米生物芯片可以将监测规模减小到纳米，并且可以成为用于监测生物分子相互作用行为的纳米平台。我们预期模仿单分子行为和一系列生物分子行为的相关性，以了解它们的巧合。

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来源
《Conference on Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications; 20080121-23; San Jose,CA(US)》|2008年|P.iviii|共2页
会议地点 San JoseCA(US)
作者
Hui-Hsin Lu; Chii-Wann Lin; Tzu-Chien Hsiao; Chih-Kung Lee; Su-Ming Hsu;
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作者单位

Institute of Electrical Engineering, National Taiwan University, Taiwan;

Institute of Biomedical Engineering, National Taiwan University, Taiwan;

Institute of Computer Science, National Chiao Tung University, Taiwan;

Institute of Applied Mechanics, National;

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会议组织
原文格式 PDF
正文语种 eng
中图分类医用物理学;
关键词
electrochemical atomic force microscopy; nano biochip; silicon dioxide nanopatterns;

机译：电化学原子力显微镜；纳米生物芯片；二氧化硅纳米图案;

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Fabrication of Silicon Dioxide Nano Array for Bio-mimicking of Molecular Interactions

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