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首页> 外文会议>Conference on Ophthalmic Technologies XIV; 20040124-20040125 and 20040127; San Jose,CA; US >Mapping retinal thickness and macular edema by high-speed three- dimensional optical coherence tomography
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Mapping retinal thickness and macular edema by high-speed three- dimensional optical coherence tomography

机译：高速三维光学相干断层扫描技术测绘视网膜厚度和黄斑水肿

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摘要

Conventional OCT generates one or few cross-sections of the retina and requires predetermination of measurement location and geometry. Because retinal pathologies are usually irregular and 3-dimensional in nature, a retinal imaging device with both high depth resolution and high lateral resolution is desired. The lateral resolution of the conventional OCT system is limited by sampling density, which in turn is limited by the speed of the system, In this paper, we present a three-dimensional optical coherence retinal tomograph (3D-OCT) which combines the rapid transversal imaging mode of a confocal scanning laser ophthalmoscope (cSLO) with the depth resolution of optical coherence tomography (OCT) to achieve high speed 3-D imaging, hi contrary to the conventional OCT which performs adjacent A-scans to form a cross-section image (B-scan) perpendicular to the retinal surface, 3D-OCT acquires section images (C-scan) parallel to the retinal surface at defined depths across the thickness of the retina. Three-dimensional distribution of light-remitting sites within the retina is recorded at a depth resolution of ～12 μm (in eye) and lateral resolution of 10μm x 20 μm within 1.2 seconds. In this paper, we present the results of in vivo retinal imaging of healthy volunteers and diabetic patients, retinal thickness mapping, and macular edema detection with the 3D-OCT device. Reproducibility of retinal thickness mapping ranges from 16 μm ～ 35 μm for different study subjects. Detailed retinal thickness map allows ready identification of location and area of macular thickening. C-scan images and continuous longitudinal cross section images provide visualization of pathological changes in the retina, such as presence of cyst formation and hard exudates. The need to predetermine measurement location and geometry is eliminated in 3D-OCT, in contrast to conventional OCT.
机译：传统的OCT会产生一个或几个视网膜横截面，并且需要预先确定测量位置和几何形状。因为视网膜病理学通常通常是不规则的并且本质上是3维的，所以期望既具有高深度分辨率又具有高横向分辨率的视网膜成像设备。传统OCT系统的横向分辨率受采样密度的限制，而采样密度又受系统速度的限制。在本文中，我们提出了一种结合了快速横向的三维光学相干视网膜断层扫描仪（3D-OCT）共焦扫描激光检眼镜（cSLO）的成像模式具有光学相干断层扫描（OCT）的深度分辨率，可实现高速3-D成像，这与传统的OCT相反，传统的OCT执行相邻的A扫描以形成横截面图像（B扫描）垂直于视网膜表面，3D-OCT会在视网膜整个厚度范围内的指定深度处获取平行于视网膜表面的切片图像（C扫描）。视网膜内发光部位的三维分布在1.2秒内以〜12μm（在眼中）的深度分辨率和10μmx 20μm的横向分辨率记录。在本文中，我们介绍了健康志愿者和糖尿病患者的体内视网膜成像，视网膜厚度图以及使用3D-OCT设备进行黄斑水肿检测的结果。不同研究对象的视网膜厚度图重现性在16μm〜35μm之间。详细的视网膜厚度图可方便识别黄斑增厚的位置和区域。 C扫描图像和连续的纵向横截面图像可直观显示视网膜中的病理变化，例如是否存在囊肿和硬性渗出液。与传统的OCT相比，在3D-OCT中无需预先确定测量位置和几何形状。

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