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首页> 外文期刊>Current Eye Research >Effects of Diabetic Macular Edema on Repeatability of Retinal Nerve Fiber Layer Thickness Measurements at the Macular and Peripapillary Area Using Swept-Source Optical Coherence Tomography
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Effects of Diabetic Macular Edema on Repeatability of Retinal Nerve Fiber Layer Thickness Measurements at the Macular and Peripapillary Area Using Swept-Source Optical Coherence Tomography

机译：使用扫描光源光学相干断层扫描的糖尿病性黄斑水肿对黄斑和围毛细区视网膜神经纤维层厚度测量的可重复性的影响

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Purpose: To investigate the repeatability of macular and peripapillary retinal nerve fiber layer (RNFL) thickness measurements made using swept-source optical coherence tomography (SS-OCT) and automated segmentation. Measurements were made in non-diabetic controls and in patients with diabetic retinopathy (DR) with or without diabetic macular edema (DME).Materials and Methods: A total of 131 eyes of 131 participants were included. Fifty-one eyes with DR had no DME (DME[-]), 45 eyes with DR had DME (DME[+]), and 35 eyes were healthy. Measurements of RNFL and full retinal thickness were simultaneously obtained with SS-OCT in the peripapillary area and in the nine Early Treatment Diabetic Retinopathy Study (ETDRS) subfields using the wide three-dimensional mode. All measurements were made twice on the same day by a single examiner to test intra-observer repeatability. Intraclass correlation coefficients (ICCs) and coefficients of repeatability were examined to evaluate repeatability.Results: Average macular and temporal peripapillary RNFL thickness values were greater in the DME[+] group (36.4 13.2 and 83.8 +/- 19.4 mu m, respectively) than in the control (27.4 +/- 3.5 and 73.5 +/- 11.4 mu m, respectively) and DME[-] (27.9 +/- 3.4 mu m and 70.3 +/- 11.3 mu m, respectively) groups (both P < 0.001). The ICCs of average macular (control: 0.982, DME[-]: 0.913, and DME[+]: 0.970) and peripapillary (control: 0.972, DME[-]: 0.973, and DME[+]: 0.958) RNFL thickness measurements indicated good repeatability in all three study groups.Conclusions: Although the ICCs of average RNFL thickness measurements were relatively lower in eyes with DR than in healthy controls, the intra-observer repeatability of SS-OCT RNFL and full retinal thickness measurements is sufficiently reliable for them to be clinically useful.
机译：目的：探讨使用扫描源光学相干断层扫描（SS-OCT）和自动分割的黄斑和围毛绒视网膜神经纤维层（RNFL）厚度测量的可重复性。在非糖尿病对照中和患有糖尿病视网膜病变（DR）的患者进行测量，有或没有糖尿病性黄斑水肿（DME）。材料和方法：包括131名参与者的131只眼睛。博士的五十一眼没有DME（DME [ - ]），45只眼睛有DME（DME [+]），35只眼睛健康。使用宽三维模式在围百树面积中和九次早期治疗糖尿病视网膜内研究（ETDRS）子场同时使用SS-OCT和全视网膜厚度的测量。所有测量在单个审查员的同一天进行两次，以测试观察者内的重复性。检查脑内相关系数（ICC）和可重复性系数以评估可重复性。结果：DME [+]组（36.4 13.2和83.8 +/- 19.4 mu m，分别比在对照（分别为27.4 +/- 3.5和73.5 +/- 11.4 mu m）和DME [ - ]（分别为27.9 +/- 3.4 mu m和70.3 +/-11.3μm）组（均为p <0.001 ）。平均黄斑的ICC（控制：0.982，DME [ - ]：0.913和DME [+]：0.970）和围网（控制：0.972，DME [ - ]：0.973和DME [+]：0.958）RNFL厚度测量在所有三个研究组中表明了良好的重复性。结论：尽管平均RNFL厚度测量的ICC与DR博士的眼睛相对较低，但SS-OCT RNFL和全视网膜厚度测量的观察室内的观察者内可重复性足够可靠他们在临床上有用。

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