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首页> 外文会议>Conference on Optical Biopsy and Tissue Optics 5-6 July 2000 Amsterdam, the Netherlands >Comparison of competing fiber optic probes for tissue fluorescence analysis
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Comparison of competing fiber optic probes for tissue fluorescence analysis

机译：用于组织荧光分析的竞争光纤探针的比较

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摘要

Several fiber optic probes attached single- or multi-fiber light delivery systems have been competitively examined for purposes of in vivo tissue fluorescence spectroscopy with endoscopic technique use. The effects of the probes' designs and excitation/receiving fiber geometry on fluorescence spectra are analyzed with the sensor optical efficiency (SOE) coefficient and the tip coupling efficiency (TCE) one calculated by means of ray tracing. The profiles of the excitation beam as well as fluorescence profiles were simulated with uniform and Gaussian cross power distributions, whereas the diameter of the tissue surface area from which fluorescence light was collected was taken as five diameter of the tissue surface area directly illuminated by the excitation beam. The plots of the SOE-coefficients versus changeable probe-tissue gap simulated possible peristaltic tissue movement during clinical in situ spectroscopic optical biopsy would be a helpful tool for specialists to design novel endoscopic fiber optic catheters to differentiate normal and pathologic tissues.
机译：为了体内组织荧光光谱和内窥镜技术的使用，已经竞争性地检查了几种附接有单根或多根光纤传输系统的光纤探针。利用传感器的光效率（SOE）系数和尖端耦合效率（TCE）（通过射线追踪计算得出），分析了探头设计和激发/接收光纤的几何形状对荧光光谱的影响。用均匀和高斯交叉功率分布模拟激发光束的轮廓以及荧光轮廓，而从中收集荧光的组织表面积的直径取为通过激发直接照射的组织表面积的五个直径光束。 SOE系数与探针组织间隙变化之间的关系图可模拟临床原位光谱光学活检过程中可能发生的蠕动组织运动，这对于专家设计新颖的内窥镜光纤导管以区分正常和病理组织将是一个有用的工具。

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