Simulation of effect of mechanical loading on dynamics of breast tissue optical properties

机译：机械载荷对乳腺组织光学特性动力学影响的模拟

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Considering enhanced angiogenesis in malignant tissues we propose in a new functional imaging technique. If proven in clinical trial, the technique may be useful for differentiating malignant tumors with enhanced vascularity from normal tissues and benign lesions. The technique is based on observing the dynamics of light attenuation in the breast tissue in response to an external pressure stimulus. The attenuation is related to blood flow and blood oxygenation. In the proposed technique the measurements are made in the red spectral wavelength region where hemoglobin serves as a natural contrast agent. In order to understand and interpret the temporal dynamic of attenuation or signatures, a model of blood circulation in zones of tumor and normal tissues is developed. The blood volume, blood flow, and oxygen saturation level are evaluated using a lumped fluid flow model incorporating published hemodynamics data obtained from biopsy samples or in-situ chamber growth of human tumor. The hemodynamics properties are translated into temporal optical attenuation profiles. We compare the optical signatures in areas with active tumor growth and in normal tissues. The results suggest that the differences in the transient response may be used as a secondary diagnostic tool in breast imaging or as a monitoring tool in anti-angiogenesis drug therapy.

机译：考虑到恶性组织中血管生成的增强，我们提出了一种新的功能成像技术。如果在临床试验中得到证实，该技术可能有助于区分具有增强的血管性的恶性肿瘤与正常组织和良性病变。该技术基于观察乳腺组织中响应外部压力刺激的光衰减动态。衰减与血流量和血液氧合有关。在提出的技术中，在血红蛋白充当天然造影剂的红色光谱波长区域中进行测量。为了理解和解释衰减或特征的时间动态，建立了肿瘤和正常组织区域的血液循环模型。使用集总流体流量模型评估血容量，血流量和氧饱和度水平，该模型结合了从活检样本或人肿瘤原位腔内生长获得的已公布的血液动力学数据。血液动力学特性转化为时间光学衰减曲线。我们比较活跃的肿瘤生长区域和正常组织中的光学信号。结果表明，瞬态反应的差异可以用作乳房成像的辅助诊断工具，也可以用作抗血管生成药物治疗的监测工具。

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《Conference on Optical Technologies in Biophysics and Medicine IV; Oct 1-4, 2002; Saratov, Russia》|2002年|p.417-431|共15页
会议地点 Saratov(RU);Saratov(RU);Saratov(RU);Saratov(RU);Saratov(RU)
作者
Alexander Dyachenko; John Gardner; Ivan Masyukov; Alan Rego; Vladimir Zlatov;
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38 Vavilova str., GPI RAS, Moscow 117942, Russia;

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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
dynamic optical image; breast cancer; angiogenesis; model of blood circulation; light attenuation;

机译：动态光学图像乳腺癌血管生成血液循环模型光衰减;

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Simulation of effect of mechanical loading on dynamics of breast tissue optical properties

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