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首页> 外文会议>Conference on Optical Tomography and Spectroscopy of Tissue V Jan 26-29, 2003 San Jose, California, USA >Hemodynamic measurements in rat brain and human muscle using diffuse near-infrared absorption and correlation spectroscopies
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Hemodynamic measurements in rat brain and human muscle using diffuse near-infrared absorption and correlation spectroscopies

机译：使用弥散近红外吸收和相关光谱在大鼠脑和人肌肉中进行血流动力学测量

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摘要

Measurement of concentration, oxygenation, and flow characteristics of blood cells can reveal information about tissue metabolism and functional heterogeneity. An improved multifunctional hybrid system has been built on the basis of our previous hybrid instrument that combines two near-infrared diffuse optical techniques to simultaneously monitor the changes of blood flow, total hemoglobin concentration (THC) and blood oxygen saturation (StO2). Diffuse correlation spectroscopy (DCS) monitors blood flow (BF) by measuring the optical phase shifts caused by moving blood cells, while diffuse photon density wave spectroscopy (DPDW) measures tissue absorption and scattering. Higher spatial resolution, higher data acquisition rate and higher dynamic range of the improved system allow us to monitor rapid hemodynamic changes in rat brain and human muscles. We have designed two probes with different source-detector pairs and different separations for the two types of experiments. A unique non-contact probe mounted on the back of a camera, which allows continuous measurements without altering the blood flow, was employed to in vivo monitor the metabolic responses in rat brain during KC1 induced cortical spreading depression (CSD). A contact probe was used to measure changes of blood flow and oxygenation in human muscle during and after cuff occlusion or exercise, where the non-contact probe is not appropriate for monitoring the moving target. The experimental results indicate that our multifunctional hybrid system is capable of in vivo and non-invasive monitoring of the hemodynamic changes in different tissues (smaller tissues in rat brain, larger tissues in human muscle) under different conditions (static versus moving). The time series images of flow during CSD obtained by our technique revealed spatial and temporal hemodynamic changes in rat brain. Two to three fold longer recovery times of flow and oxygenation after cuff occlusion or exercise from calf flexors in a patient with peripheral vascular disease (PVD) were found.
机译：血细胞浓度，氧合和血流特性的测量可以揭示有关组织代谢和功能异质性的信息。在我们以前的混合仪器的基础上，构建了一种改进的多功能混合系统，该仪器结合了两种近红外漫射光学技术，以同时监测血流，总血红蛋白浓度（THC）和血氧饱和度（StO2）的变化。扩散相关光谱法（DCS）通过测量由移动的血细胞引起的光学相移来监控血流（BF），而扩散光子密度波光谱法（DPDW）则用于测量组织吸收和散射。改进后的系统具有更高的空间分辨率，更高的数据采集速率和更高的动态范围，使我们能够监控大鼠脑和人体肌肉中的快速血液动力学变化。我们针对两种类型的实验设计了两种具有不同源-检测器对和不同间隔的探针。安装在相机背面的独特非接触式探针可在不改变血流量的情况下进行连续测量，用于体内监测KC1诱导的皮层扩张抑制（CSD）期间大鼠脑中的代谢反应。接触式探针用于测量袖带闭塞或运动期间和运动后人体肌肉中血流和氧合的变化，其中非接触式探针不适用于监测运动目标。实验结果表明，我们的多功能混合系统能够在不同条件下（静态与运动）在体内和非侵入性地监测不同组织（大鼠脑中的较小组织，人肌肉中的较大组织）的血液动力学变化。通过我们的技术获得的CSD期间血流的时间序列图像揭示了大鼠大脑的时空血流动力学变化。在患有周围血管疾病（PVD）的患者中，发现袖带闭塞或小腿屈肌运动后的血流和氧合恢复时间延长了2到3倍。

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