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首页> 外文期刊>Physics in medicine and biology. >In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies.
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In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies.

机译：体内脑血管测量结合了漫反射近红外吸收和相关光谱。

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摘要

We combine two near-infrared diffuse optical techniques to study variations of blood flow, haemoglobin concentration, and blood oxygen saturation in the functioning rat brain. Diffuse correlation spectroscopy (or flowmetry) monitors changes in the cerebral blood flow, without the use of the principles of tracer clearance, by measuring the optical phase-shifts caused by moving blood cells. Near-infrared absorption spectroscopy concurrently measures tissue absorption at two wavelengths to determine haemoglobin concentration and blood oxygen saturation in this same tissue volume. This optical probe is non-invasive and was employed through the intact skull. The utility of the technique is demonstrated in vivo by measuring the temporal changes in the regional vascular dynamics of rat brain during hypercapnia. Temporal and spatial variations of cerebral blood flow, haemoglobin concentration and blood oxygen saturation during hypercapnia are compared with other measurements in the literature, and a quantitative analysis demonstrating the self-consistency of our combined observations of vascular response is presented.
机译：我们结合两种近红外漫射光学技术来研究功能正常的大鼠大脑中血流量，血红蛋白浓度和血氧饱和度的变化。扩散相关光谱法（或流量计）通过测量由移动的血细胞引起的光学相移，在不使用示踪剂清除原理的情况下监测脑血流的变化。近红外吸收光谱法同时测量两个波长下的组织吸收率，以确定该相同组织体积中的血红蛋白浓度和血氧饱和度。该光学探针是非侵入性的，并通过完整的头骨使用。通过测量高碳酸血症期间大鼠脑区域血管动力学的时间变化，可以证明该技术的实用性。将高碳酸血症期间脑血流量，血红蛋白浓度和血氧饱和度的时空变化与文献中的其他测量结果进行比较，并给出定量分析，证明我们对血管反应的综合观察的自洽性。

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