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首页> 外文会议>Conference on Optics in Tissue Engineering and Regenerative Medicine; 20080120-21; San Jose,CA(US) >Imaging of artificial cartilage with optical coherence tomography
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Imaging of artificial cartilage with optical coherence tomography

机译：光学相干断层扫描成像的人工软骨成像

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Tissue Engineering methods have become more and more relevant for orthopedic applications, especially for cartilage repair with autologous chondrocytes. In order to monitor the healing process and bonding between cartilage and the artificial implant, the boundary zone must be imaged non-invasively, for example with OCT. Optical Coherence Tomography (OCT) is a short coherent light based measuring technique which allows the generation of cross-section images of semi-transparent media with a depth resolution of up to 5 μm and a measuring depth of 1-2 mm. Especially for the imaging of cartilage OCT offers new diagnostic possibilities, as conventional methods such as ultrasound and x-ray imaging often do not yield satisfactory resolution or contrast. In this paper, an OCT measurement setup for imaging of human cartilage tissue with OCT is demonstrated, allowing a detection of local damaging and lesions. Furthermore, both compressed and uncompressed collagen gel pads were implanted into human cartilage samples. OCT measurements are presented for samples in different stages of growth, focusing on the boundary zones. Comparisons with histologies are shown, demonstrating the ability of OCT to enable a monitoring of the healing progress in tissue engineering based therapy.
机译：组织工程方法对于骨科应用，尤其是自体软骨细胞的软骨修复，变得越来越重要。为了监视愈合过程以及软骨与人造植入物之间的结合，必须使用例如OCT对边界区域进行非侵入性成像。光学相干断层扫描（OCT）是一种基于短相干光的测量技术，可生成深度分辨率高达5μm，测量深度为1-2 mm的半透明介质的横截面图像。尤其对于软骨成像，OCT提供了新的诊断可能性，因为常规方法（如超声和X射线成像）通常无法产生令人满意的分辨率或对比度。在本文中，演示了使用OCT对人软骨组织进行成像的OCT测量设置，可检测局部损伤和病变。此外，将压缩的和未压缩的胶原凝胶垫都植入人软骨样品中。提出了针对不同生长阶段样品的OCT测量，重点是边界区域。显示了与组织学的比较，证明了OCT能够监控基于组织工程的疗法的愈合过程。

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