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首页> 外文会议>Conference on Photon Processing in Microelectronics and Photonics III; 20040126-20040129; San Jose,CA; US >Cell/surface interactions on laser micro-textured titanium-coated silicon surfaces
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Cell/surface interactions on laser micro-textured titanium-coated silicon surfaces

机译：激光微织构钛涂层硅表面上的细胞/表面相互作用

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摘要

This paper presents the results of recent efforts to improve the biocompatibility and integration of implantable bioMEMS devices. Laser micro-grooves and micro-grids were irradiated onto silicon surfaces using ultraviolet lasers. The micro-textured surfaces were then coated with nano-scale layers of titanium to promote improved biocompatibility. The micro-groove geometries have been shown to promote contact guidance, which leads to reduced scar tissue formation. In contrast, smooth surfaces result in random cell orientations and the increased possibility of scar tissue formation. The nature of the cellular attachment and adhesion to the coated/uncoated micro-textured surfaces was elucidated by the visualization of the cells through scanning electron microscopy. Finally, the implications of the results are discussed for integration of silicon-based microelectronics and sensors into biological systems.
机译：本文介绍了最近为改善可植入生物MEMS器件的生物相容性和集成性而做出的努力的结果。使用紫外激光将激光微槽和微格栅照射到硅表面上。然后在微织构表面上涂覆纳米级的钛层，以促进改善的生物相容性。已经证明，微槽几何形状可促进接触引导，从而减少疤痕组织的形成。相反，光滑的表面会导致随机的细胞方向，并增加形成疤痕组织的可能性。通过扫描电子显微镜对细胞的可视化，阐明了细胞附着的性质以及对涂覆/未涂覆的微织构表面的粘附性。最后，讨论了将硅基微电子和传感器集成到生物系统中的结果含义。

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