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首页> 外文会议>Conference on Physiology and Function: Methods, Systems, and Applications Feb 16-18, 2003 San Diego, California, USA >Estimation of Pressure Gradients at Renal Artery Stenoses
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Estimation of Pressure Gradients at Renal Artery Stenoses

机译：肾动脉狭窄的压力梯度估计

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摘要

Atherosclerotic disease of the renal artery can reduce the blood flow to leading to renovascular hypertension and ischemic nephopathy. The kidney responds to a decrease in blood flow by activation of the renin-angiotensin system that increases blood pressure and can result in severe hypertension. Percutaneous translumenal angioplasty (PTA) may be indicated for treatment of renovascular hypertenion (RVH). However, direct measurement of renal artery caliber and degree of stenosis has only moderate specificity for detection of RVH. A confounding factor in assessment of the proximal renal artery is that diffuse atherosclerotic disease of the distal branches of the renal artery can produce the same effect on blood-flow as atherosclerotic disease of the proximal renal artery. A methodology is proposed for estimation of pressure gradients at renal artery stenoses from magnetic resonance imaging that could improve the evaluation of renal artery disease. In the proposed methodology, pressure gradients are estimated using computational fluid dynamics (CFD) modeling. Realistic CFD models are constructed from images of vessel shape and measurements of blood-flow rates which are available from magnetic resonance angiography (MRA) and phase-contrast magnetic resonance (MR) imaging respectively. CFD measurement of renal artery pressure gradients has been validated in a physical flow-through model.
机译：肾动脉的动脉粥样硬化疾病可减少血流量，导致肾血管性高血压和缺血性肾病。肾脏通过激活肾素-血管紧张素系统来响应血流量的减少，从而增加血压并可能导致严重的高血压。经皮腔内血管成形术（PTA）可用于治疗肾血管性高血压（RVH）。但是，直接测量肾动脉口径和狭窄程度对RVH的检测仅具有中等特异性。评估近端肾动脉的一个混杂因素是，肾动脉远端分支的弥漫性动脉粥样硬化疾病可对血流产生与近端肾动脉动脉粥样硬化疾病相同的影响。提出了一种通过磁共振成像估计肾动脉狭窄处压力梯度的方法，该方法可以改善肾动脉疾病的评估。在提出的方法中，使用计算流体动力学（CFD）建模估算压力梯度。现实的CFD模型是根据血管形状的图像和血流速度的测量结果构建的，这些图像分别可以从磁共振血管造影（MRA）和相衬磁共振（MR）成像中获得。肾动脉压力梯度的CFD测量已在物理流通模型中得到验证。

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