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首页> 外文会议>Conference on Physiology and Function: Methods, Systems, and Applications Feb 16-18, 2003 San Diego, California, USA >CT Measurement of Indomethacin Induced Cerebral Hemodnamic Changes in the Newborn Piglet
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CT Measurement of Indomethacin Induced Cerebral Hemodnamic Changes in the Newborn Piglet

机译：吲哚美辛诱导新生仔猪脑血流变化的CT测量

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摘要

Patent ductus arteriosus (PDA), a common condition among preterm infants, increases the risk of intraventricular hemorrhage, bronchopulmonary dysplasia, and death in afflicted individuals. Current clinical treatment of PDA relies on use of the drug indomethacin to close the ductus arteriosus. In the present study, we have investigated the effect of indomethacin on cerebral blood flow (CBF), cerebral blood volume (CBV), and cerebral mean transit time (MTT) in newborn piglets using computed tomography (CT) perfusion. Twenty newborn piglets divided by age into two groups, < 12 hours of age (n = 10) and > 12 hours of age (n = 10) were studied. Five piglets in each group received indomethacin treatment (0.2 mg/kg infused over 30 min) while remaining piglets served as controls. No significant changes in CBF were observed in control groups. In both indomethacin treated groups, average CBF decreased 32.3 % and 34.3 % (P> 0.05) below baseline immediately post infusion in piglets less than and greater than 12 hours of age respectively. Piglets less than 12 hours of age treated with indomethacin also exhibited a delayed increase in CBF, maximum average increase of 41.7 % (P> 0.05) above baseline at 210 min post infusion, a response not observed hi the corresponding group of piglets greater than 12 hours of age. The observed age dependent response may be due to functional/anatomical closure of the PDA.
机译：动脉导管未闭（PDA）是早产儿的常见病状，增加了患病个体发生脑室内出血，支气管肺发育不良和死亡的风险。当前PDA的临床治疗依赖于使用吲哚美辛来闭合动脉导管。在本研究中，我们使用计算机断层扫描（CT）灌注研究了消炎痛对新生仔猪脑血流量（CBF），脑血容量（CBV）和脑平均通过时间（MTT）的影响。研究了20只新生仔猪，按年龄将其分为两组，分别为<12小时龄（n = 10）和> 12小时龄（n = 10）。每组五只仔猪接受吲哚美辛治疗（在30分钟内注入0.2 mg / kg），其余仔猪作为对照。在对照组中，没有观察到CBF的明显变化。在两个吲哚美辛治疗组中，输注后小于和大于12小时的仔猪的平均CBF分别比基线降低了32.3％和34.3％（P> 0.05）。吲哚美辛治疗的小于12小时龄的仔猪也表现出CBF的延迟增加，在输注后210分钟时比基线最大平均增加41.7％（P> 0.05），在相应组的大于12的仔猪中未观察到反应小时的年龄。观察到的年龄依赖性反应可能是由于PDA的功能/解剖闭合所致。

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