...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of applied physiology >Near-infrared spectroscopy measurements of cerebral blood flow and oxygen consumption following hypoxia-ischemia in newborn piglets.
【24h】

Near-infrared spectroscopy measurements of cerebral blood flow and oxygen consumption following hypoxia-ischemia in newborn piglets.

机译：新生仔猪缺氧缺血后脑血流量和耗氧量的近红外光谱测量。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Impaired oxidative metabolism following hypoxia-ischemia (HI) is believed to be an early indicator of delayed brain injury. The cerebral metabolic rate of oxygen (CMRO2) can be measured by combining near-infrared spectroscopy (NIRS) measurements of cerebral blood flow (CBF) and cerebral deoxy-hemoglobin concentration. The ability of NIRS to measure changes in CMRO2 following HI was investigated in newborn piglets. Nine piglets were subjected to 30 min of HI by occluding both carotid arteries and reducing the fraction of inspired oxygen to 8%. An additional nine piglets served as sham-operated controls. Measurements of CBF, oxygen extraction fraction (OEF), and CMRO2 were obtained at baseline and at 6 h after the HI insult. Of the three parameters, only CMRO2 showed a persistent and significant change after HI. Five minutes after reoxygenation, there was a 28+/-12% (mean+/-SE) decrease in CMRO2, a 72+/-50% increase in CBF, and a 56+/-19% decrease in OEF compared with baseline (P<0.05). By 30 min postinsult and for the remainder of the study, there were no significant differences in CBF and OEF between control and insult groups, whereas CMRO2 remained depressed throughout the 6-h postinsult period. This study demonstrates that NIRS can measure decreases in CMRO2 caused by HI. The results highlight the potential for NIRS to be used in the neonatal intensive care unit to detect delayed brain damage.
机译：缺氧缺血（HI）后氧化代谢受损被认为是延迟性脑损伤的早期指标。可以通过结合脑血流量（CBF）和脑脱氧血红蛋白浓度的近红外光谱（NIRS）测量来测量脑氧代谢（CMRO2）。在新生仔猪中研究了NIRS测量HI后CMRO2变化的能力。通过阻塞两个颈动脉并使吸入氧气的比例降至8％，对9头小猪进行HI 30分钟。另外9头仔猪用作假手术对照。在基线和HI损伤后6小时获得CBF，氧提取分数（OEF）和CMRO2的测量值。在这三个参数中，只有CMRO2在HI后显示出持续且显着的变化。复氧后五分钟，与基线相比，CMRO2降低了28 +/- 12％（平均+/- SE），CBF增加了72 +/- 50％，OEF降低了56 +/- 19％（ P ＜0.05）。到感染后30分钟以及在本研究的其余部分中，对照组和感染组之间的CBF和OEF均无显着差异，而CMRO2在整个感染后6小时内仍处于抑制状态。这项研究表明，NIRS可以测量由HI引起的CMRO2降低。结果突出显示了NIRS在新生儿重症监护病房中用于检测延迟性脑损伤的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号