The Synthesis of an Antiviral Fluorinated Purine Nucleoside: 3'-α-Fluoro-2',3'-dideoxyguanosine

机译：抗病毒氟化嘌呤核苷的合成：3'-α-氟-2'，3'-二脱氧鸟苷

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In this review, the synthesis of FddG, a potential HIV reverse transcriptase inhibitor is described focusing on regio- and stereoselective fluorination at the C3'α-position of the nucleoside. These results, which include a synthetic strategy employing retentive fluorination, may provide a new approach towards a variety of C3'α -substituted nucleosides.

机译：在这篇综述中，描述了潜在的HIV逆转录酶抑制剂FddG的合成，着重于核苷C3'α位的区域和立体选择性氟化。这些结果，包括采用保持性氟化的合成策略，可以提供针对各种C3'α-取代核苷的新方法。

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《Current fluoroorganic chemistry : New synthetic directions, technologies, materials, and biological applications》|2005年|363-378|共16页
会议地点 Washington DC(US);Washington DC(US)
作者
Kunisuke Izawa; rnTakayoshi Torii; Tomoyuki Onishi; Tokumi Maruyama;
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作者单位

AminoScience Laboratories, Ajinomoto Company, Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, Japan 210-8681;

rnAminoScience Laboratories, Ajinomoto Company, Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, Japan 210-8681;

rnAminoScience Laboratories, Ajinomoto Company, Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, Japan 210-8681;

rnFaculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Shido 1314-1, Sanuki-city, Kagawa, Japan 769-2193;

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正文语种 eng
中图分类氟及其化合物;
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入库时间 2022-08-26 14:19:54

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2. Design and Synthesis of 3 '-Deoxy-3 '-Fluoro-2 '-O,3 '-C-Vinylene-Linked Bicyclic Purine Nucleoside [J] . Zhao BJ, Chang JB, Wang Q, Synlett . 2008,第19期

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3. Synthesis of (1'-fluoro-2',2'-bis-(hydroxymethyl)cyclopropylmethyl)purines as antiviral agents. [J] . Park JH, Choi MH, Jeong LS, Nucleosides, nucleotides and nucleic acids . 2003,第5a8期

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4. Aqueous Phase Sonogashira Cross-Coupling Reaction in Synthesis of Bile Acid Conjugates of Purine and Pyrimidine Nucleosides and Nucleoside Triphosphates; Towards Bile Acid -Functionalized Nucleic Acids [C] . Satu Ikonen, Radek Pohl, Michal Hocek European Symposium on Organic Chemistry . 2009

机译：水相Sonogashira交叉偶联反应在嘌呤和嘧啶核苷的合成中合成，嘧啶核苷和核苷三磷酸盐;朝向胆汁酸 - 官能化核酸
5. Purine and pyrimidine carbocyclic nucleosides as antiviral agents. [D] . Bailey, Elaine LeCreurer. 2004

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6. Synthesis and antiviral activity of 2′-deoxy-2′-fluoro-2′-C-methyl-7-deazapurine nucleosides their phosphoramidate prodrugs and 5′-triphosphates [O] . Junxing Shi, Longhu Zhou, Hongwang Zhang, -1

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7. Versatile synthesis and biological evaluation of novel 3’-fluorinated purine nucleosides [O] . Hang Ren, Haoyun An, Paul J. Hatala, 2015

机译：新型3'-氟化嘌呤核苷的通用合成和生物学评价

The Synthesis of an Antiviral Fluorinated Purine Nucleoside: 3'-α-Fluoro-2',3'-dideoxyguanosine

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