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Positive Darwinian Selection in Gene Evolution

机译:基因进化中的正达尔文选择

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When Charles Darwin proposed the theory of evolution by natural selection,he was concemed with phenotypic evolution.Because all phenotypes have their genetic basis,natural selection indirectly acts on genotypes through its action on phenotypes.In this article,I review the roles of positive Darwinian selection in the evolution of genes,focusing on the work conducted in my laboratory in the last decade.Using real examples,I show that different forms of positive selection can promote amino acid substitutions,cause parallel amino acid changes,increase the rate of insertion/deletion substitutions,accelerate gene loss,and enhance gene expression noise.Although positive selection probably does not account for the majority of changes in DNA sequence evolution,it can and did shape DNA sequence evolution in many different ways and is undoubtedly an important force in molecular evolution.
机译:当查尔斯·达尔文提出自然选择进化理论时,他被认为是表型进化。由于所有表型都有其遗传基础,自然选择通过其对表型的作用而间接作用于基因型。在本文中,我回顾了阳性达尔文主义的作用。基因进化中的基因选择,重点是我在过去十年中在实验室中所做的工作。通过真实的例子,我证明了不同形式的正选择可以促进氨基酸取代,引起平行的氨基酸变化,提高插入率/尽管正选择可能不能解释DNA序列进化的大部分变化,但它可以并且确实以多种不同的方式影响DNA序列的进化,并且无疑是分子中的重要力量。演化。

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