• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II >Management of all three phases of wound healing through the induction of fluorescence biomodulation using fluorescence light energy
【24h】

Management of all three phases of wound healing through the induction of fluorescence biomodulation using fluorescence light energy

机译：通过使用荧光能量诱导荧光生物调节来管理伤口愈合的所有三个阶段

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Research on photobiomodulation (PBM) has led to the development of various light-generating devices that can benefit awide range of clinical indications. A novel approach of inducing PBM is through application of a FluorescenceBiomodulation (FB) System consisting of a blue light (peak wavelength between 440 and 460 nm) which activatestopical photoconverter substrates containing specialized chromophores that generate fluorescence light energy (FLE). Inclinical trials, FLE has been shown to modulate both healthy and disease-affected skin/soft tissue, providing a uniquemethod for managing inflammatory skin conditions and accelerating healing. To better understand the biological impactof FB-induced FLE, we studied this system in vitro on dermal human fibroblasts (DHFs) and in vivo in canine deeppyoderma.In vitro data from stimulated DHFs exposed to an FB System showed a significant decrease in IL-6 production by130.14% after 24 hr (p<0.001), compared to control groups. In canines with chronic deep pyoderma, the use of FB plusstandard of care (SOC) treatment significantly reduced time to clinical resolution compared to controls that receivedSOC alone (p<0.001). Biopsies from lesional areas showed enhanced mitochondrial biogenesis in the FB lesions versusthe SOC lesions, as supported by a significant increase in the number and size of mitochondria (89.31% and 90.15%respectively; p<0.0001). Significant modulation of inflammatory pathways, epithelialization, and angiogenesis were alsodemonstrated.These results support the use of FB Systems for skin conditions impacted by inflammation and offer a promisingtherapeutic solution to support its use in other medical conditions.
机译：对光生物调节（PBM）的研究已导致开发出各种有益于人体健康的发光设备。 临床适应症广泛。诱导PBM的新方法是通过应用荧光 生物调制（FB）系统由蓝光（峰值波长在440和460 nm之间）组成，可激活 局部光电转换器基材，包含产生荧光能量（FLE）的专用生色团。在 临床试验表明，FLE可调节健康和受疾病影响的皮肤/软组织，从而提供独特的功能。 治疗炎症性皮肤病和促进愈合的方法。为了更好地了解生物影响 FB诱导的FLE，我们在真皮人成纤维细胞（DHF）上进行了体外研究，并在犬深层体内进行了研究 脓皮病。 暴露于FB系统的受刺激DHF的体外数据显示，IL-6的产生显着降低。 与对照组相比，24小时后达到130.14％（p <0.001）。在患有慢性深脓皮病的犬中，使用FB plus 与接受对照组相比，护理标准（SOC）治疗显着减少了达到临床解决的时间 仅SOC（p <0.001）。与相比，病变区域的活组织检查显示FB病变中线粒体的生物发生增强 线粒体数量和大小的显着增加支持了SOC病变（89.31％和90.15％ 分别; p <0.0001）。炎症途径，上皮形成和血管生成的显着调节也 演示。 这些结果支持将FB Systems用于受炎症影响的皮肤状况，并提供了有希望的方法 治疗性溶液以支持其在其他医疗条件下的使用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号