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首页> 外文会议>Diagnostic Optical Spectroscopy in Biomedicine IV; Progress in Biomedical Optics and Imaging; vol.8 no.41; Proceedings of SPIE-The International Society for Optical Engineering; vol.6628 >Detection of early bronchial cancer by autofluorescence: results in patients with HN cancer
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Detection of early bronchial cancer by autofluorescence: results in patients with HN cancer

机译：自体荧光检测早期支气管癌：H＆N癌症患者的结果

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摘要

Head and neck (H&N) cancer patients have a high incidence of second primary tumors in the tracheobronchial tree. Diagnostic autofluorescence endoscopy (DAFE) has shown promising results in the detection of early neoplastic and pre-neoplastic changes in the bronchi. We have investigated the medical impact of DAFE in a population of H&N cancer patients. The bronchoscopies were performed using a modified commercially available DAFE system, allowing both white light (WL) and autofluorescence (AF) bronchoscopy. Endoscopic imaging of the tissue AF was combined with an online image analysis procedure allowing to discriminate between true and false positive results. Twenty-one H&N cancer patients with a high risk of bronchial cancer underwent WL and AF bronchoscopy with this improved system. Forty-one biopsies were taken on macroscopically suspicious (WL or AF positive) bronchial sites. Histopathologic analysis confirmed pre- or early neoplastic changes in 11 of these biopsies taken from 8 patients. The sensitivity for the detection of these early lesions with the DAFE was 1.6 times larger than the sensitivity of WL bronchoscopy only. The positive predictive value (PPV) for AF was 79% (33% for WL alone). The PPV of both methods together was 100%. DAFE proved to be efficient for the detection of second primary lesions in H&N cancer patients. It can thus be used as a simple additional procedure to pre-operative or follow-up examination in this patient population.
机译：头颈部（H＆N）癌症患者在气管支气管树中第二原发肿瘤的发生率很高。诊断性自发荧光内窥镜检查（DAFE）在检测支气管的早期肿瘤和肿瘤前变化中显示出令人鼓舞的结果。我们已经研究了DAFE对H＆N癌症患者群体的医学影响。支气管镜检查使用改良的市售DAFE系统进行，可同时进行白光（WL）和自发荧光（AF）支气管镜检查。组织AF的内窥镜成像与在线图像分析程序相结合，可区分真假结果。借助这种改进的系统，对21例高支气管癌H＆N癌症患者进行了WL和AF支气管镜检查。在宏观可疑的（WL或AF阳性）支气管部位进行了41次活检。组织病理学分析证实了从8例患者中进行的11例活检中的肿瘤发生前或早期肿瘤改变。用DAFE检测这些早期病变的灵敏度仅是WL支气管镜检查的灵敏度的1.6倍。 AF的阳性预测值（PPV）为79％（仅WL为33％）。两种方法的PPV均为100％。事实证明，DAFE可有效检测H＆N癌症患者的第二原发灶。因此，它可以用作该患者人群术前或随访检查的简单附加程序。

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