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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Improvement of the specificity of cancer detection by autofluorescence imaging in the tracheo-bronchial tree using backscattered violet light
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Improvement of the specificity of cancer detection by autofluorescence imaging in the tracheo-bronchial tree using backscattered violet light

机译：利用反向散射紫光，通过自发荧光成像在气管支气管树中提高癌症检测的特异性

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摘要

Background: Autofluorescence bronchoscopy (AFB) is a highly sensitive tool for the detection of early bronchial cancers. However, its specificity remains limited due to primarily false positive results induced by hyperplasia, metaplasia and inflammation. We have investigated the potential of blue-violet backscattered light to eliminate false positive results during AFB in a clinical pilot study. Methods: The diagnostic autofluorescence endoscopy (DAFE) system was equipped with a variable band pass filter in the imaging detection path. The backscattering properties of normal and abnormal bronchial mucosae were assessed by computing the contrast between the two tissue types for blue-violet wavelengths ranging between 410 and 490 nm in 12 patients undergoing routine DAFE examination. In a second study including 6 patients we used a variable long pass (LP) filter to determine the spectral design of the emission filter dedicated to the detection of this blue-violet light with the DAFE system. Results: (Pre-)neoplastic mucosa showed a clear wavelength dependence of the backscattering properties of blue-violet light while the reflectivity of normal, metaplastic and hyperplastic autofluorescence positive mucosa was wavelength independent. Conclusions: Our results showed that the detection of blue-violet light has the potential to reduce the number of false positive results in AFB. In addition we determined the spectral design of the emission filter dedicated to the detection of this blue-violet light with the DAFE system.
机译：背景：自体荧光支气管镜检查（AFB）是用于检测早期支气管癌的高度敏感的工具。然而，由于由增生，化生和炎症引起的主要假阳性结果，其特异性仍然受到限制。在一项临床试验研究中，我们已经研究了蓝紫色反向散射光消除AFB期间假阳性结果的潜力。方法：诊断性自发荧光内窥镜检查（DAFE）系统在成像检测路径上装有可变带通滤光片。正常和异常支气管粘膜的反向散射特性是通过计算12种接受常规DAFE检查的患者的蓝紫色波长在410 nm至490 nm之间的两种组织之间的对比度来评估的。在包括6位患者的第二项研究中，我们使用了可变长通（LP）滤波器来确定专用于使用DAFE系统检测这种蓝紫色光的发射滤波器的光谱设计。结果：（前）肿瘤粘膜对蓝紫色光的反向散射特性具有明显的波长依赖性，而正常，化生和增生自体荧光阳性粘膜的反射率与波长无关。结论：我们的结果表明，检测蓝紫色光可以减少AFB中假阳性结果的数量。此外，我们确定了专​​用于使用DAFE系统检测这种蓝紫色光的发射滤光片的光谱设计。

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