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Non-contact assessment of obstructive sleep apnea cardiovascular biomarkers using photoplethysmography imaging

机译:使用光体积描记术成像非阻塞性评估阻塞性睡眠呼吸暂停心血管生物标志物

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摘要

Obstructive sleep apnea (OSA) affects 20% of the adult population, and is associated with cardiovascular and cognitive morbidities. However, it is estimated that up to 80% of treatable OSA cases remain undiagnosed. Current methods for diagnosing OSA are expensive, labor-intensive, and involve uncomfortable wearable sensors. This study explored the feasibility of non-contact biophotonic assessment of OSA cardiovascular biomarkers via photoplethysmography imaging (PPGI). In particular. PPGI was used to monitor the hemodynamic response to obstructive respiratory events. Sleep apnea onset was simulated using Muller's maneuver in which breathing was obstructed by a respiratory clamp. A custom PPGI system, coded hemodynamic imaging (CHI), was positioned 1 m above the bed and illuminated the participant's head with 850 nm light, providing non-intrusive illumination for night-time monitoring. A video was recorded before, during and following an apnea event at 60 fps, yielding 17 ms temporal resolution. Per-pixel absorbance signals were extracted using a Beer-Lambert derived light transport model, and subsequently denoised. The extracted hemodynamic signal exhibited dynamic temporal modulation during and following the apnea event. In particular, the pulse wave amplitude (PWA) decreased during obstructed breathing, indicating vasoconstriction. Upon successful inhalation, the PWA gradually increased toward homeostasis following a temporal phase delay. This temporal vascular tone modulation provides insight into autonomic and vascular response, and may be used to assess sleep apnea using non-contact biophotonic imaging.
机译:阻塞性睡眠呼吸暂停(OSA)影响20%的成年人口,并与心血管疾病和认知疾病相关。但是,据估计高达80%的可治疗OSA病例仍未得到诊断。当前用于诊断OSA的方法昂贵,费力且涉及不舒适的可穿戴传感器。这项研究探讨了通过光电容积描记成像(PPGI)进行OSA心血管生物标志物非接触生物光子评估的可行性。特别是。 PPGI用于监测对阻塞性呼吸事件的血液动力学反应。使用穆勒的手法模拟了睡眠呼吸暂停的发作,其中呼吸受到呼吸钳的阻碍。定制的PPGI系统(编码血流动力学成像(CHI))位于病床上方1 m处,并用850 nm的光线照亮了参与者的头部,为夜间监控提供了非侵入式照明。在呼吸暂停事件之前,期间和之后以60 fps录制视频,产生17 ms的时间分辨率。使用Beer-Lambert导出的光传输模型提取每个像素的吸光度信号,然后进行去噪。所提取的血液动力学信号在呼吸暂停事件期间和之后表现出动态的时间调制。特别是,在呼吸阻塞期间脉搏波幅度(PWA)降低,表明血管收缩。成功吸入后,PWA在一段时间的相位延迟后逐渐趋于稳态。这种暂时性的血管紧张度调节提供了对自主神经和血管反应的洞察力,并可用于通过非接触式生物光子成像评估睡眠呼吸暂停。

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  • 来源
  • 会议地点 San Francisco(US)
  • 作者单位

    Department of Systems Design Engineering, University of Waterloo, 200 University Ave W,Waterloo, Canada,Schlcgel-University of Waterloo Research Institute for Aging, 250 Laurelwood Dr. Waterloo, Canada;

    Department of Systems Design Engineering, University of Waterloo, 200 University Ave W,Waterloo, Canada,Schlcgel-University of Waterloo Research Institute for Aging, 250 Laurelwood Dr. Waterloo, Canada;

    Department of Systems Design Engineering, University of Waterloo, 200 University Ave W,Waterloo, Canada;

    Department of Systems Design Engineering, University of Waterloo, 200 University Ave W,Waterloo, Canada;

    Department of Systems Design Engineering, University of Waterloo, 200 University Ave W,Waterloo, Canada,Schlcgel-University of Waterloo Research Institute for Aging, 250 Laurelwood Dr. Waterloo, Canada;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Photoplethysmography imaging; remote photoplethysmography; sleep apnea; non-contact; pulse wave amplitude;

    机译:光体积描记术成像;远程光体积描记术睡眠呼吸暂停;非接触脉搏波幅度;

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