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首页> 外文会议>Optical diagnostics and sensing XVIII: Toward Point-of-Care Diagnostics >Proximal Design for a Multimodality Endoscope with Multiphoton Microscopy, Optical Coherence Microscopy and Visual Modalities
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Proximal Design for a Multimodality Endoscope with Multiphoton Microscopy, Optical Coherence Microscopy and Visual Modalities

机译：具有多光子显微镜，光学相干显微镜和视觉模态的多模态内窥镜的近端设计

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摘要

A multimodality endoscope system has been designed for early detection of ovarian cancer. Multiple illumination and detection systems must be integrated in a compact, stable, transportable configuration to meet the requirements of a clinical setting. The proximal configuration presented here supports visible light navigation with a large field of view and low resolution, high resolution multiphoton microscopy (MPM), and high resolution optical coherence microscopy (OCM). All modalities are integrated into a single optical system in the endoscope. The system requires two light sources: a green laser for visible light navigation and a compact fiber based femtosecond laser for MPM and OCM. Using an inline wavelength division multiplexer, the two sources are combined into a single mode fiber. To accomplish OCM, a fiber coupler is used to separate the femtosecond laser into a reference arm and signal arm. The reflected reference arm and the signal from the sample are interfered and wavelength separated by a reflection grating and detected using a linear array. The MPM signal is collimated and goes through a series of filters to separate the 2nd and 3rd harmonics as well as two-photon excitation florescence (2PEF) and 3PEF. Each signal is independently detected on a photo multiplier tube and amplified. The visible light is collected by multiple high numerical aperture fibers at the endoscope tip which are bundled into one SMA adapter at the proximal end and connected to a photodetector. This integrated system design is compact, efficient and meets both optical and mechanical requirements for clinical applications.
机译：已经设计了一种多模态内窥镜系统，用于早期发现卵巢癌。多个照明和检测系统必须以紧凑，稳定，可运输的配置集成在一起，以满足临床环境的要求。这里介绍的近端配置支持具有大视野和低分辨率，高分辨率多光子显微镜（MPM）和高分辨率光学相干显微镜（OCM）的可见光导航。所有形式都集成到内窥镜的单个光学系统中。该系统需要两个光源：用于可见光导航的绿色激光器和用于MPM和OCM的紧凑型基于光纤的飞秒激光器。使用串联波分复用器，将两个光源组合成单模光纤。为了完成OCM，使用光纤耦合器将飞秒激光分为参考臂和信号臂。反射的参考臂和来自样品的信号受到干扰，并由反射光栅进行波长分离，并使用线性阵列进行检测。 MPM信号经过准直，并经过一系列滤波器以分离第二和第三谐波以及双光子激发荧光（2PEF）和3PEF。每个信号在光电倍增管上独立检测并放大。可见光由内窥镜尖端的多条高数值孔径光纤收集，这些光纤在近端捆绑成一个SMA适配器并连接到光电探测器。这种集成的系统设计紧凑，高效，可满足临床应用的光学和机械要求。

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