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In-vivo quantitative measurement of tissue oxygen saturation of human webbing using a transmission type continuous-wave near-infrared spectroscopy

机译:使用透射型连续波近红外光谱技术进行人体安全带组织氧饱和度的体内定量测量

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Near-infrared spectroscopy (NIRS) is a noninvasive method for monitoring tissue oxygen saturation (StO_2). Many commercial NIRS devices are presently available. However, the precision of those devices is relatively poor because they are using the reflectance-model with which it is difficult to obtain the blood volume and other unchanged components of the tissue. Human webbing is a thin part of the hand and suitable to measure spectral transmittance. In this paper, we present a method for measuring StO_2 of human webbing from a transmissive continuous-wave near-infrared spectroscopy (CW-NIRS) data. The method is based on the modified Beer-Lambert law (MBL) and it consists of two steps. In the first step, we give a pressure to the upstream region of the measurement point to perturb the concentration of deoxy- and oxy-hemoglobin as remaining the other components and measure the spectral signals. From the measured data, spectral absorbance due to the components other than hemoglobin is calculated. In the second step, spectral measurement is performed at arbitrary time instance and the spectral absorbance obtained in the step 1 is subtracted from the measured absorbance. The tissue oxygen saturation (StO_2) is estimated from the remained data. The method was evaluated on an arterial occlusion test (AOT) and a venous occlusion test (VOT). In the evaluation experiment, we confirmed that reasonable values of StO_2 were obtained by the proposed method.
机译:近红外光谱(NIRS)是一种用于监视组织氧饱和度(StO_2)的非侵入性方法。目前有许多商用NIRS设备。但是,这些设备的精度相对较差,因为它们使用的是反射模型,难以获得血液量和组织的其他不变成分。人体安全带是手的一小部分,适合测量光谱透射率。在本文中,我们提出了一种从透射连续波近红外光谱(CW-NIRS)数据测量人织带StO_2的方法。该方法基于修改后的比尔-朗伯定律(MBL),它包括两个步骤。在第一步中,我们向测量点的上游区域施加压力,以扰动其余部分的脱氧和氧合血红蛋白浓度,并测量光谱信号。根据测量数据,计算归因于血红蛋白以外的成分的光谱吸收率。在第二步骤中,在任意时间执行光谱测量,并从测量的吸光度中减去在步骤1中获得的光谱吸光度。根据剩余数据估算组织氧饱和度(StO_2)。该方法在动脉闭塞试验(AOT)和静脉闭塞试验(VOT)上进行了评估。在评估实验中,我们确认通过所提出的方法可以获得合理的StO_2值。

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