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首页> 外文会议>Optical diagnostics and sensing XVIII: Toward Point-of-Care Diagnostics >Evaluation and benchmarking of an EC-QCL-based mid-infrared spectrometer for monitoring metabolic blood parameters in critical care units
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Evaluation and benchmarking of an EC-QCL-based mid-infrared spectrometer for monitoring metabolic blood parameters in critical care units

机译：基于EC-QCL的中红外光谱仪的评估和基准测试，用于监测重症监护病房中的代谢性血液参数

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Mid-infrared spectroscopy hyphenated with micro-dialysis is an excellent method for monitoring metabolic blood parameters as it enables the concurrent, reagent-free and precise measurement of multiple clinically relevant substances such as glucose, lactate and urea in micro-dialysates of blood or interstitial fluid. For a marketable implementation, quantum cascade lasers (QCL) seem to represent a favourable technology due to their high degree of miniaturization and potentially low production costs. In this work, an external cavity (EC) - QCL-based spectrometer and two Fourier-transform infrared (FTIR) spectrometers were benchmarked with regard to the precision, accuracy and long-term stability needed for the monitoring of critically ill patients. For the tests, ternary aqueous solutions of glucose, lactate and mannitol (the latter for dialysis recovery determination) were measured in custom-made flow-through transmission cells of different pathlengths and analyzed by Partial Least Squares calibration models. It was revealed, that the wavenumber tuning speed of the QCL had a severe impact on the EC-mirror trajectory due to matching the digital-analog-converter step frequency with the mechanical resonance frequency of the mirror actuation. By selecting an appropriate tuning speed, the mirror oscillations acted as a hardware smoothing filter for the significant intensity variations caused by mode hopping. Besides the tuning speed, the effects of averaging over multiple spectra and software smoothing parameters (Savitzky-Golay-filters and FT-smoothing) were investigated. The final settings led to a performance of the QCL-system, which was comparable with a research FTIR-spectrometer and even surpassed the performance of a small FTIR-mini-spectrometer.
机译：具有微透析功能的中红外光谱技术是监测代谢血液参数的绝佳方法，因为它可以同时，无试剂和精确地测量血液或间质微透析液中多种临床相关物质，例如葡萄糖，乳酸和尿素体液。对于适销对路的实现，量子级联激光器（QCL）似乎由于其高度的小型化和较低的生产成本而代表了一种有利的技术。在这项工作中，基于外腔（EC）-基于QCL的光谱仪和两个傅里叶变换红外（FTIR）光谱仪在监测重症患者所需的精度，准确性和长期稳定性方面进行了基准测试。为了进行测试，在不同光程的定制流通式传输池中测量了葡萄糖，乳酸和甘露醇的三元水溶液（后者用于透析恢复的测定），并通过偏最小二乘校准模型进行了分析。结果表明，QCL的波数调谐速度由于使数模转换器阶跃频率与镜面致动的机械共振频率匹配而对EC镜面轨迹产生了严重影响。通过选择适当的调谐速度，镜面振荡可充当硬件平滑滤波器，以消除由模式跳变引起的明显强度变化。除了调谐速度之外，还研究了对多个频谱求平均值以及软件平滑参数（Savitzky-Golay滤波器和FT平滑）的影响。最终设置带来了QCL系统的性能，该性能可与研究型FTIR光谱仪相媲美，甚至超过了小型FTIR微型光谱仪的性能。

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