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首页> 外文会议>Diffuse Optical Imaging of Tissue; Progress in Biomedical Optics and Imaging; vol.8 no.42; Proceedings of SPIE-The International Society for Optical Engineering; vol.6629 >First clinical trials of the Twente Photoacoustic Mammoscope (PAM)
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First clinical trials of the Twente Photoacoustic Mammoscope (PAM)

机译：Twente光声乳房镜（PAM）的首次临床试验

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摘要

Breast cancer dominates cancers in females. This burden on society and the room for improvements in the current practice of mammography have been stimuli for developing new modalities like photoacoustic mammography. At the University of Twente (UT), an instrument had been developed aimed at performing limited area scans on the human breast. This instrument is called the Twente Photoacoustic Mammoscope (PAM). The PAM is based on generating laser-induced ultrasound from absorbing structures in the breast. The heart of the instrument is a flat PVDF based detector matrix comprising 590 active elements. We show the performance characteristics of the ultrasound detector. The exciting source is an Nd:YAG laser operating at 1064 nm with 5 ns pulses. A study protocol was designed to explore the feasibility of using the PAM to detect cancer in the breasts of patients. The protocol was executed at the Medisch Spectrum Twente by using the mammoscope to obtain photoacoustic region-of-interest (ROI) images of the suspect/symptomatic breasts. We compare the photoacoustic images obtained with x-ray mammograms and ultrasound images. We show photoacoustic images of ROI in one case where we attribute high intensity regions to tumor vascularization.
机译：乳腺癌在女性中占主导地位。这种对社会的负担以及当前乳腺X射线照相术的改进空间已经刺激了人们开发诸如光声乳腺X射线照相术的新形式。在特温特大学（UT），已经开发了一种仪器，旨在对人的乳房进行有限区域扫描。该仪器称为Twente光声乳房镜（PAM）。 PAM基于从乳房中的吸收结构产生激光诱导的超声波。该仪器的核心是一个基于PVDF的扁平检测器矩阵，包含590个有源元件。我们展示了超声波探测器的性能特征。令人兴奋的光源是Nd：YAG激光器，其工作波长为1064 nm，脉冲时间为5 ns。设计了一项研究方案，以探讨使用PAM检测患者乳房中癌症的可行性。通过使用乳腺镜在Medisch Spectrum Twente上执行该协议，以获取可疑/有症状乳房的光声关注区域（ROI）图像。我们比较用X射线乳房X线照片和超声图像获得的光声图像。我们在一种情况下显示ROI的光声图像，其中我们将高强度区域归因于肿瘤血管形成。

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