Depth-resolved Optical Imaging of Hemodynamic Response in Mouse Brain within Microcirculatory Beds

机译：深度解析光学成像在微循环床上的小鼠脑部血流动力学反应。

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Optical hemodynamic imaging employed in pre-clinical studies with high spatial and temporal resolution is significant to unveil the functional activities of brain and the mechanism of internal or external stimulus effects in diverse pathological conditions and treatments. Most current optical systems only resolve hemodynamic changes within superficial macro-circulatory beds, such as laser speckle contrast imaging; or only provide vascular structural information within micro-circulatory beds, such as multi-photon microscopy. In this study, we introduce a hemodynamic imaging system based on Optical Micro-angiography (OMAG) which is capable of resolving and quantifying 3D dynamic blood perfusion down to microcirculatory level. This system can measure the optical phase shifts caused by moving blood cells in microcirculation. Here, the utility of OMAG was demonstrated by monitoring the hemodynamic response to alcohol administration in mouse prefrontal cortex. Our preliminary results suggest that the spatiotemporal tracking of cerebral micro-hemodynamic using OMAG can be successfully applied to the mouse brain and reliably distinguish between vehicle and alcohol stimulation experiment.

机译：临床前研究中采用的具有高时空分辨率的光学血流动力学成像对于揭示大脑的功能活动以及在各种病理条件和治疗中内部或外部刺激作用的机制具有重要意义。当前大多数光学系统只能解决浅层大循环床内的血液动力学变化，例如激光散斑对比成像。或仅在微循环床内提供血管结构信息，例如多光子显微镜。在这项研究中，我们介绍了一种基于光学微血管造影（OMAG）的血液动力学成像系统，该系统能够解析和量化直至微循环水平的3D动态血液灌注。该系统可以测量微循环中血细胞移动引起的光学相移。在这里，通过监测小鼠前额叶皮层中酒精对血液动力学的响应，证明了OMAG的实用性。我们的初步结果表明，使用OMAG对大脑微血流动力学进行时空跟踪可以成功地应用于小鼠大脑，并且可以可靠地区分媒介物和酒精刺激实验。

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来源
《Dynamics and fluctuations in biomedical photonics VIII》|2011年|p.789812.1-789812.4|共4页
会议地点 San Francisco CA(US)
作者
Yali Jia; Rosemary Nettleton; Mara Rosenberg; Eilis Boudreau; Ruikang K Wang;
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作者单位

Department of Bioengineering, University of Washington, Seattle, WA 98195, USA;

Department of Neurology, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA;

Department of Neurology, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA;

Department of Neurology, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA;

Department of Bioengineering, University of Washington, Seattle, WA 98195, USA;

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原文格式 PDF
正文语种 eng
中图分类医用物理学;
关键词
optical microangiography; microcirculation; hemodynamic response;

机译：光学微血管造影微循环血液动力学反应;

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1. Exploring diazepam’s effect on hemodynamic responses of mouse brain tissue by optical spectroscopic imaging [J] . David Abookasis, Ariel Shochat, Elimelech Nesher, Biomedical Optics Express . 2014,第7期

机译：通过光谱分析探索地西epa对小鼠脑组织血液动力学反应的影响
2. Transcranial optical vascular imaging (TOVI) of cortical hemodynamics in mouse brain [J] . Vyacheslav Kalchenko, David Israeli, Yuri Kuznetsov, Scientific reports. . 2014,第1期

机译：小鼠大脑皮层血流动力学的经颅光学血管成像（TOVI）
3. In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain. [J] . Kassandra Kisler, Divna Lazic, Melanie D Sweeney, Nature protocols erecipes for researchers . 2018,第6期

机译：小鼠脑中脑血管血流动力学反应及组织氧合的体内成像及分析。
4. Depth-resolved Optical Imaging of Hemodynamic Responsein Mouse Brain with in Microcirculatory Beds [C] . Yali Jia, Rosemary Nettleton, Mara Rosenberg, SPIE Conference on Dynamics and Fluctuations in Biomedical Photonics . 2011

机译：微循环床中小鼠脑中血流动力学反应的深度分辨光学成像
5. Imaging and Quantification of Microcirculatory Network within Tissue Beds in vivo using Optical Coherence Tomography. [D] . Yousefi, Siavash. 2014

机译：使用光学相干层析成像技术对体内组织床中的微循环网络进行成像和定量分析。
6. Exploring diazepam’s effect on hemodynamic responses of mouse brain tissue by optical spectroscopic imaging [O] . David Abookasis, Ariel Shochat, Elimelech Nesher, 2014

机译：用光谱成像研究地西epa对小鼠脑组织血液动力学反应的影响
7. Imaging hemodynamic response after ischemic stroke in mouse cortex using visible-light optical coherence tomography [O] . Siyu Chen, Qi Liu, Xiao Shu, 2016

机译：使用可见光光学相干断层扫描在小鼠皮层中缺血性脑卒中后的成像血液动力学反应

Depth-resolved Optical Imaging of Hemodynamic Response in Mouse Brain within Microcirculatory Beds

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