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首页> 外文会议>Dynamics and fluctuations in biomedical photonics XI >Multi-parametric imaging of cerebral hemodynamic and metabolic response followed by ischemic injury
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Multi-parametric imaging of cerebral hemodynamic and metabolic response followed by ischemic injury

机译：脑血流动力学和代谢反应继发缺血性损伤的多参数成像

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摘要

We use rodent parietal cortex as a model system and utilize a synchronized dual wavelength laser speckle imaging (SDW-LSCI) technique to explore the hemodynamic response of infarct and penumbra to a brain injury (middle cerebral artery occlusion (MCAO) model). The SDW-LSCI system is able to take snapshots rapidly (maximum 500 Hz) over the entire brain surface, providing key information about the hemodynamic response, in terms of which it may be used to elucidate evolution of penumbra region from onsite to 90 min of MCAO. Changes in flow are quantified as to the flow experiencing physical occlusions of the MCA normalized to that of baseline. Furthermore, the system is capable of providing information as to the changes of the concentration of oxygenated, (HbO) deoxygenated (Hb), and total hemoglobin (HbT) in the cortex based on the spectral characteristics of HbO and Hb. We observe that the oxygenation variations in the four regions are detectable and distinct. Combining the useful information, four regions of interest (ROI), infarct, penumbra, reduced flow and contralateral portions in the brain upon ischemic injury may be differentiated. Implications of our results are discussed with respect to current understanding of the mechanisms underlying MCAO. We anticipate that SDW-LSCI holds promise for rapid and large field of view localization of ischemic injury.
机译：我们使用啮齿动物的顶叶皮层作为模型系统，并利用同步双波长激光散斑成像（SDW-LSCI）技术来探索梗塞和半影对脑损伤的血液动力学反应（大脑中动脉阻塞（MCAO）模型）。 SDW-LSCI系统能够在整个大脑表面上快速拍摄快照（最大500 Hz），提供有关血液动力学反应的关键信息，据此可以用来阐明半影区域从原位到90分钟的演变。 MCAO。流量的变化被量化为MCA物理阻塞的流量被标准化为基线。此外，该系统能够基于HbO和Hb的光谱特征，提供皮质中的氧化，脱氧（HbO）和总血红蛋白（HbT）浓度变化的信息。我们观察到在四个区域中的氧合变化是可检测的并且是不同的。结合有用的信息，可以区分缺血损伤时大脑中的四个感兴趣区域（ROI），梗塞，半影，血流减少和对侧部分。关于当前对MCAO潜在机制的理解，讨论了我们的结果的含义。我们预计SDW-LSCI有望在缺血性损伤的快速和大视野定位中发挥作用。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Jia Qin; Lei Shi; Suzan Dziennis; Ruikang K. Wang;

  • 作者单位

    Division of Biomedical Engineering, Department of Automation Engineering, Northeastern University at Qinhuangdao, Hebei 066004, China Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA;

    Division of Biomedical Engineering, Department of Automation Engineering, Northeastern University at Qinhuangdao, Hebei 066004, China Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA;

    Division of Biomedical Engineering, Department of Automation Engineering, Northeastern University at Qinhuangdao, Hebei 066004, China Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA;

    Division of Biomedical Engineering, Department of Automation Engineering, Northeastern University at Qinhuangdao, Hebei 066004, China Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    laser speckle; hemodynamic; oxygenation; ischemic injury;

    机译：激光斑点血液动力学氧合缺血性损伤;

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