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Flexible TMS coil for reducing inter-individual variabilities in clinical use

机译：柔性TMS线圈可减少临床使用中的个体差异

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Transcranial Magnetic Stimulation (TMS) is a painless and noninvasive procedure for treating neurological and psychiatric brain disorders. Coils matched with the target curvatures exhibit optimized properties. However, patients have different head topologies, which makes it difficult for a rigid coil to fit all patients. In this study, we developed a rubber-like flexible coil that can be shaped into different geometries according to the target curvatures, greatly reducing the challenges of inter-individual variabilities in clinical use, and investigated the influence of bending on the electromagnetic and mechanical characterization of this coil. The magnetic field distribution was calculated based on the Ampere's law with Maxwell's addition. The coil efficiency, was simulated using custom-made software based on scalar potential finite difference (SPFD) methods. We measured the magnetic flux induced by our prototype with a search coil. The induced Lorentz force of the coil was calculated based on Ampere's force law, and measured with a pressure sensor. Fatigue analysis was carried out with ANSYS both on external bending force and Lorentz force. The results show the eddy current density induced by the flexible coil is significantly stronger than the figure-8 coil and butterfly coil in most cases. And human hand bending force (less than 1 k N) and pressure (～0.1 MPa) caused by the Lorentz force lead to a sufficiently long coil lifetime.
机译：经颅磁刺激（TMS）是一种无痛且无创的治疗神经和精神病性脑部疾病的方法。与目标曲率匹配的线圈表现出优化的性能。但是，患者的头部拓扑结构不同，这使得刚性线圈难以适合所有患者。在这项研究中，我们开发了一种橡胶状柔性线圈，可以根据目标曲率成型为不同的几何形状，从而大大降低了临床使用中个体间差异的挑战，并研究了弯曲对电磁和机械特性的影响该线圈的。磁场分布是根据安培定律和麦克斯韦的加法计算出来的。使用基于标量电势有限差分（SPFD）方法的定制软件来模拟线圈效率。我们用搜索线圈测量了原型产生的磁通量。根据安培力定律计算线圈的感应洛伦兹力，并用压力传感器进行测量。用ANSYS对外部弯曲力和洛伦兹力进行了疲劳分析。结果表明，在大多数情况下，柔性线圈引起的涡流密度明显强于8型线圈和蝶形线圈。洛伦兹力引起的人手弯曲力（小于1 k N）和压力（〜0.1 MPa）导致足够长的线圈寿命。

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