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Antimicrobial Outcomes in Plasma Medicine

机译：血浆医学中的抗菌治疗结果

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Plasma is referred to as the fourth state of matter and is frequently generated in the environment of a strong electric field. The result consists of highly reactive species-ions, electrons, reactive atoms and molecules, and UV radiation. Plasma Medicine unites a number of fields, including Physics, Plasma Chemistry, Cell Biology, Biochemistry, and Medicine. The treatment modality utilizes Cold Atmospheric Plasma (CAP), which is able to sterilize and treat microbes in a nonthermal manner. These gas-based plasma systems operate at close to room temperature and atmospheric pressure, making them very practical for a range of potential treatments and are highly portable for clinical use throughout the health care system. The hypothesis is that gas based plasma kills bacteria, fungus, and viruses but spares mammalian cells. This paper will review systematic work which shows examples of systems and performance in regards to antimicrobial effects and the sparing of mammalian cells. The mechanism of action will be discussed, as well as dosing for the treatment of microbial targets, including sterilization processes, another important healthcare need. In addition, commercial systems will be overviewed and compared, along with evidence-based, patient results. The range of treatments cover wound treatment and biofilms, as well as antimicrobial treatment, with little chance for resistance and tolerance, as in drug regimens. Current clinical studies include applications in dentistry, food treatment, cancer treatment, wound treatment for bacteria and biofilms, and systems to combat health care related infections.
机译：等离子体被称为物质的第四种状态，通常在强电场的环境中产生。结果包括高反应性的物种离子，电子，反应性原子和分子以及紫外线辐射。血浆医学联合了许多领域，包括物理，等离子体化学，细胞生物学，生物化学和医学。该治疗方式利用冷大气等离子体（CAP），它能够以非加热方式对微生物进行灭菌和处理。这些基于气体的等离子体系统在接近室温和大气压的条件下运行，使其在一系列潜在治疗中非常实用，并且在整个医疗保健系统中都非常便于临床使用。假设是基于气体的血浆可以杀死细菌，真菌和病毒，但可以拯救哺乳动物细胞。本文将回顾系统的工作，该工作显示了有关抗菌作用和节省哺乳动物细胞方面的系统和性能的实例。将讨论作用机理以及用于治疗微生物靶标的剂量，包括灭菌过程，这是另一个重要的医疗保健需求。此外，还将对商业系统以及基于证据的患者结果进行概述和比较。治疗的范围包括伤口治疗和生物膜以及抗菌治疗，与药物治疗方案一样，耐药和耐受的机会很小。当前的临床研究包括在牙科，食品治疗，癌症治疗，细菌和生物膜的伤口治疗以及与医疗保健相关的感染进行对抗的系统中的应用。

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