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Alternating magnetic field optimization for IONP hyperthermia cancer treatment

机译：交替磁场优化用于IONP热疗癌症治疗

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摘要

Iron oxide nanoparticles (IONP) have therapeutic potential to deliver a thermal dose to tumors when activated in an alternating magnetic field (AMF). Through various targeting methods such as antibody labeling or injection site choice, delivery of IONPs to tumors yields enhanced treatment accuracy and efficacy. Despite this advantage, delivery an AMF, which is sufficient to result in clinically relevant IONP heating, can result in non-specific tissue heating via the generation of eddy currents and tissue permeated by local electric fields (joule heating). The production of eddy current heating is a function of tissue size, geometry and composition as well as coil design and operation. The purpose of this research is to increase the level of energy deposited into the IONPs versus the non-target tissue (power ratio/PR)1 in order to improve target heating and reduce non-specific tissue damage. We propose to improve the PR using two primary concepts: (1) reduce power deposition into non-target tissue by manipulating the fields and eddy current flow and (2) enhance heat removal from non-target tissue. We have shown that controlling tissue placement within the AMF field, accounting for tissue geometry, utilizing external cooling devices, and modifying the field properties can decrease non-target heating by more than 50%, at clinically relevant AMF levels, thereby allowing for an increase in thermal dose to the tumor and increasing the therapeutic ratio.
机译：当在交变磁场（AMF）中激活时，氧化铁纳米粒子（IONP）具有向肿瘤传递热剂量的治疗潜力。通过各种靶向方法，例如抗体标记或注射位点选择，将IONP递送至肿瘤可提高治疗准确性和功效。尽管有这个优点，但递送足以导致临床上相关的IONP加热的AMF，可能会通过产生涡电流和局部电场渗透的组织（焦耳加热）而导致非特异性组织加热。涡流加热的产生是组织尺寸，几何形状和成分以及线圈设计和操作的函数。这项研究的目的是增加与非目标组织相比沉积在IONPs中的能量水平（功率比/ PR）1，以改善目标加热并减少非特异性组织损伤。我们建议使用两个主要概念来改善PR：（1）通过操纵磁场和涡流来减少向非目标组织的功率沉积；（2）增强从非目标组织的散热。我们已经表明，在临床相关的AMF水平下，控制AMF场内的组织放置，考虑组织的几何形状，利用外部冷却设备以及修改场属性可以将非目标加热减少50％以上。对肿瘤的热剂量和增加治疗率。

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