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Contribution of a 300kHz alternating magnetic field on magnetic hyperthermia treatment of HepG2 cells

机译：300kHz交变磁场对HepG2细胞磁热疗的贡献

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We investigated the relative contributions of temperature and a 300kHz alternating magnetic field (AMF) on magnetic hyperthermia treatment (MHT). Our system consisted of an induction coil, which generated AMF by electric current flow, and a newly developed, temperature-controlled circulating water-jacketed glass bottle placed inside the coil. The AMF generator operated at a frequency of 300kHz with variable field strength ranging from 0 to 11mT. Four treatment conditions were employed: (A) control (37°C, 0mT), (B) AMF exposure (37°C, 11mT), (C) hyperthermia (46°C, 0mT), and (D) hyperthermia plus AMF exposure (46°C, 11mT) for 30min. Cell viability and apoptotic death rate were estimated. The relative contributions or interactions of hyperthermia (46°C) and AMF (11mT) on MHT were evaluated using 2×2 factorial experiment analysis. Group A was statistically different (P<0.05) from each of the other treatments. The observed effects on both cell viability and apoptotic cell death were influenced by temperature (97.36% and 92.15%, respectively), AMF (1.78% and 4.99%, respectively), and the interactions between temperature and AMF (0.25% and 2.36%, respectively). Thus, the effect of hyperthermia was significant. Also, AMF exposure itself might play a role in MHT, although these observations were made in vitro. These findings suggest a possible presence of an AMF effect during clinical magnetic hyperthermia.
机译：我们调查了温度和300kHz交变磁场（AMF）对磁热疗（MHT）的相对贡献。我们的系统包括一个感应线圈，该感应线圈通过电流产生AMF，一个新开发的温度控制的循环水套式玻璃瓶放置在线圈内部。 AMF发生器的工作频率为300kHz，场强范围为0至11mT。采用四种治疗条件：（A）对照（37°C，0mT），（B）AMF暴露（37°C，11mT），（C）高温（46°C，0mT），以及（D）高温加AMF暴露（46°C，11mT）30分钟。估计细胞活力和凋亡死亡率。使用2×2析因实验分析评估了高温（46°C）和AMF（11mT）对MHT的相对贡献或相互作用。 A组与其他每种治疗在统计学上均存在差异（P <0.05）。温度（分别为97.36％和92.15％），AMF（分别为1.78％和4.99％）和温度与AMF之间的相互作用（分别为0.25％和2.36％）影响了观察到的对细胞活力和凋亡性细胞死亡的影响。分别）。因此，热疗效果显着。同样，尽管这些观察是在体外进行的，但AMF暴露本身可能在MHT中起作用。这些发现表明在临床磁热疗期间可能存在AMF效应。

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