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首页> 外文会议>FED-vol.261; American Society of Mechanical Engineers(ASME) International Mechanical Engineering Congress and Exposition; 20051105-11; Orlando,FL(US) >A HIGH FIDELITY ELECTROKINETIC FLOW MODEL FOR THE PREDICTION OF ELECTROPHOREGRAMS IN ON-CHIP ELECTROPHORESIS APPLICATIONS
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A HIGH FIDELITY ELECTROKINETIC FLOW MODEL FOR THE PREDICTION OF ELECTROPHOREGRAMS IN ON-CHIP ELECTROPHORESIS APPLICATIONS

机译：用于预测芯片上电泳应用中电泳图的高保真电动模型

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摘要

On-chip electrophoresis is a growing field with increasing chemical and bioanalytical applications such as genomics and proteomics. The use of multicomponent and heterogeneous electrolyte configurations can often lead to complex flow behavior. In this work, we present a high-fidelity, low computational cost electrokinetic flow model for the modeling and optimization of electrophoretic separations. The model adopts a depth-averaged approach that captures convective-dispersion processes, and includes important physical effects such as electrical body force and fully nonlinear multi-species electromigration. The corresponding numerical scheme is based on a finite volume approach using a monotonic upstream-centered construction (MUSCL). The numerical model can simulate arbitrary electrolyte and sample configurations, and capture the complex evolution of sharp, narrow sample peaks and high pre-concentration (stacking) ratios. Exemplary results showing both field amplified sample stacking and isotachophoresis processes are presented. The development of such models is critical to the efficient design and optimization of on-chip CE methods and devices.
机译：片上电泳是一个不断发展的领域，具有越来越多的化学和生物分析应用，例如基因组学和蛋白质组学。多组分和非均质电解质配置的使用通常会导致复杂的流动行为。在这项工作中，我们提出了一种高保真，低计算成本的电动流动模型，用于电泳分离的建模和优化。该模型采用深度平均方法来捕获对流弥散过程，并包括重要的物理效应，例如，电场力和完全非线性的多物种电迁移。相应的数值方案基于使用单调上游中心构造（MUSCL）的有限体积方法。数值模型可以模拟任意的电解质和样品配置，并捕获尖锐，窄样品峰和高预浓缩（堆积）比的复杂变化。给出了示例性结果，显示了现场放大的样品堆叠和等速电泳过程。此类模型的开发对于有效设计和优化片上CE方法和设备至关重要。

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