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首页> 外文会议>Fiber optic sensors and applications VIII >Surface scattering plasmon resonance fibre sensors: demonstration of rapid influenza A virus detection
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Surface scattering plasmon resonance fibre sensors: demonstration of rapid influenza A virus detection

机译：表面散射等离子体共振纤维传感器：快速检测甲型流感病毒的演示

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The management of threats such as pandemics and explosives, and of health and the environment requires the rapid deployment of highly sensitive detection tools. Sensors based on Surface Plasmon Resonance (SPR) allow rapid, labelfree, highly sensitive detection, and indeed this phenomenon underpins the only label-free optical biosensing technology that is available commercially. In these sensors, the existence of surface plasmons is inferred indirectly from absorption features that correspond to the coupling of light to the surface plasmon. Although SPR is not intrinsically a radiative process, under certain conditions the surface plasmon can itself couple to the local photon states, and emit light as first described byKretschmann. Here we show that by collecting and characterising this re-emitted light, it is possible to realise new SPR sensing architectures that are more compact, versatile and robust than existing approaches. This approach addresses existing practical limitations associated with current SPR technologies, including bulk, cost and calibration. It is applicable to a range of SPR geometries, including optical fibres, planar waveguides and prism configurations, and is in principle capable of detecting multiple analytes simultaneously. Moreover, this technique allows to combine SPR sensing and fluorescence sensing into a single platform which has never been demonstrated before and consequently use these two methods for a more reliable diagnostic. As an example, this approach has been used to demonstrate the rapid detection of the seasonal influenza virus.
机译：对流行病和爆炸物等威胁以及健康和环境的管理要求迅速部署高度敏感的检测工具。基于表面等离子体共振（SPR）的传感器可以快速，无标签，高度灵敏地进行检测，实际上，这种现象巩固了唯一可商购的无标签光学生物传感技术。在这些传感器中，表面等离激元的存在是根据与光耦合到表面等离激元的吸收特征间接推断的。尽管SPR本质上不是辐射过程，但在某些条件下，表面等离子体激元本身可以耦合到局部光子状态，并如Kretschmann首次描述的那样发光。在这里，我们表明，通过收集和表征这种重新发射的光，可以实现比现有方法更紧凑，多功能和更坚固的新SPR传感体系结构。该方法解决了与当前SPR技术相关的现有实际限制，包括批量，成本和校准。它适用于各种SPR几何形状，包括光纤，平面波导和棱镜配置，并且原则上能够同时检测多种分析物。而且，该技术允许将SPR感测和荧光感测组合到一个以前从未证明过的单一平台中，因此可以使用这两种方法进行更可靠的诊断。例如，此方法已被用来证明季节性流感病毒的快速检测。

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